Smith D H, Scott D L, Zaphiropoulos G C
Ann Rheum Dis. 1983 Aug;42(4):408-10. doi: 10.1136/ard.42.4.408.
Cross-sectional and longitudinal studies have been carried out to determine the incidence and clinical significance of eosinophilia in patients taking penicillamine for rheumatoid arthritis. In a cross-sectional study of 204 patients eosinophilia was found with equal frequency during treatment with penicillamine, gold, and nonsteroidal anti-inflammatory drugs. A longitudinal study of 89 patients treated with penicillamine showed no consistent relationship between eosinophilia and adverse reactions to the drug. It is concluded that routine monitoring of eosinophil counts is unlikely to be of value in the management of patients taking penicillamine.
已开展横断面研究和纵向研究，以确定服用青霉胺治疗类风湿性关节炎的患者中嗜酸性粒细胞增多症的发生率及临床意义。在一项针对204例患者的横断面研究中，发现服用青霉胺、金制剂和非甾体抗炎药治疗期间出现嗜酸性粒细胞增多症的频率相同。一项针对89例接受青霉胺治疗患者的纵向研究表明，嗜酸性粒细胞增多症与该药物的不良反应之间不存在一致的关联。得出的结论是，常规监测嗜酸性粒细胞计数对服用青霉胺的患者管理不太可能有价值。
