State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510655, China.
State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China.
J Environ Manage. 2019 May 1;237:519-525. doi: 10.1016/j.jenvman.2019.02.102. Epub 2019 Feb 28.
Persistent organic pollutants (POPs) and endocrine disrupting compounds (EDCs) are almost ubiquitous in synthetic and natural sources; however these contaminants adversely impact ecosystems and humans. Owing to their potential toxicity, concerns have been raised about the effects of POPs and EDCs on ecological and human health. Therefore, toxicity evaluation and mechanisms actions of these contaminants are of great interest. The nematode Caenorhabditis elegans (C. elegans), an excellent model animal for environmental toxicology research, has been used widely for toxicity studies of POPs or EDCs from the whole-animal level to the single-cell level. In this review, we have discussed the toxicity of specific POPs or EDCs after acute, chronic, and multigenerational exposure in C. elegans. We have also introduced a discussion of the toxicological mechanisms of these compounds in C. elegans, with respect to oxidative stress, cell apoptosis, and the insulin/IGF-1 signaling pathway. Finally, we raised considered the perspectives and challenges of the toxicity assessments, multigenerational toxicity, and toxicological mechanisms.
持久性有机污染物（POPs）和内分泌干扰化合物（EDCs）几乎无处不在，无论是在合成来源还是自然来源中；然而，这些污染物会对生态系统和人类健康造成不良影响。由于它们潜在的毒性，人们对 POPs 和 EDCs 对生态和人类健康的影响表示担忧。因此，这些污染物的毒性评估和作用机制引起了广泛关注。秀丽隐杆线虫（C. elegans）是环境毒理学研究的优秀模式动物，已广泛用于研究 POPs 或 EDCs 的毒性，从整体动物水平到单细胞水平。在这篇综述中，我们讨论了特定的 POPs 或 EDCs 在急性、慢性和多代暴露后在 C. elegans 中的毒性。我们还介绍了这些化合物在 C. elegans 中的毒理学机制，包括氧化应激、细胞凋亡和胰岛素/IGF-1 信号通路。最后，我们提出了对毒性评估、多代毒性和毒理学机制的展望和挑战。
