Horjus Deborah L, Bokslag Anouk, Hooijberg Femke, Hutten Barbara A, Middeldorp Saskia, de Groot Christianne J M
Amsterdam UMC, University of Amsterdam, Vascular Medicine, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
Amsterdam UMC, Vrije Universiteit Amsterdam, Obstetrics and Gynecology, Amsterdam Cardiovascular Sciences, de Boelelaan 1117, 1081 HV Amsterdam, Netherlands.
Pregnancy Hypertens. 2019 Jan;15:118-122. doi: 10.1016/j.preghy.2018.12.009. Epub 2018 Dec 31.
High plasma creatine kinase (CK) activity is associated with hypertension in the general and pregnant population. We hypothesize that women with a history of early-onset preeclampsia are prone to hypertension due to a high CK activity level.
Nine to 16 years after pregnancy, serum CK activity and blood pressure were measured in 117 women with a history of early-onset preeclampsia and 50 women with a history of an uncomplicated pregnancy.
CK activity levels of the two groups were compared using the Mann-Whitney U test. The association between CK activity and blood pressure was evaluated by means of multivariable regression analysis.
There was no significant difference in median (interquartile range) CK activity between women with a history of early-onset preeclampsia and an uncomplicated pregnancy (59.00 [47.00-85.00] vs. 58.00 [46.50-75.25], respectively, p = 0.774). The association between CK and systolic blood pressure was significant in women with a pregnancy history of early-onset preeclampsia (regression coefficient [95% confidence interval]: 0.123 mmHg [0.020-0.226], p = 0.019), and a trend was found for diastolic blood pressure (p = 0.069). CK and blood pressure were not significantly associated in women with a history of an uncomplicated pregnancy.
Median CK did not significantly differ between the two groups. Serum CK activity was significantly associated with systolic blood pressure in women with a history of early-onset preeclampsia. These data suggest that CK is not a predominant factor in the increased risk of hypertension in women with a history of early-onset preeclampsia.
在普通人群和孕妇中，高血浆肌酸激酶（CK）活性与高血压相关。我们假设，有早发型子痫前期病史的女性由于CK活性水平高而易于患高血压。
在产后9至16年，对117例有早发型子痫前期病史的女性和50例有正常妊娠病史的女性测量血清CK活性和血压。
使用Mann-Whitney U检验比较两组的CK活性水平。通过多变量回归分析评估CK活性与血压之间的关联。
有早发型子痫前期病史的女性和正常妊娠的女性之间，中位数（四分位间距）CK活性无显著差异（分别为59.00[47.00 - 85.00]和58.00[46.50 - 75.25]，p = 0.774）。在有早发型子痫前期妊娠史的女性中，CK与收缩压之间的关联显著（回归系数[95%置信区间]：0.123 mmHg[0.020 - 0.226]，p = 0.019），舒张压有此趋势（p = 0.069）。有正常妊娠病史的女性中，CK与血压无显著关联。
两组之间的中位数CK无显著差异。有早发型子痫前期病史的女性中，血清CK活性与收缩压显著相关。这些数据表明，CK不是有早发型子痫前期病史女性高血压风险增加的主要因素。
