一种从光电容积脉搏波导出的新型参数，用于区分先兆子痫和非先兆子痫。

A novel parameter derived from photoplethysmographic pulse wave to distinguish preeclampsia from non-preeclampsia.

作者信息

Chen Hang, Jiang Feng, Drzymalski Dan, Chen Wanlin, Feng Ying, Miao Jiajun, Jiao Cuicui, Chen Xinzhong

机构信息

College of Biomedical Engineering and Instrument Science, Zhejiang University, China; Key Lab of Biomedical Engineering of Ministry of Education, Zhejiang University, China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, China.

Tufts Medical Center, Department of Anesthesiology, Boston, MA, USA.

出版信息

Pregnancy Hypertens. 2019 Jan;15:166-170. doi: 10.1016/j.preghy.2019.01.005. Epub 2019 Jan 11.

DOI:10.1016/j.preghy.2019.01.005

PMID:30825916

Abstract

OBJECTIVE

To describe the comparative hierarchical area ratio (CHAR), a novel parameter derived from the photoplethysmographic (PPG) pulse wave and differences in CHAR values in parturients with and without preeclampsia (PE).

METHODS

A total of 59 parturients (37 without and 22 with PE) was conducted at the Women's Hospital, Zhejiang University, School of Medicine in Hangzhou, China. We calculated the CHAR values derived from the PPG pulse wave and compared them in parturients with and without PE.

RESULT

The values of CHAR derived from the parturients with PE were lower compared to those without PE (p < 0.01). The ROC analysis indicated that the best threshold for the mean value of CHAR was 7.92 to predict PE with a sensitivity of 86.4% and a specificity of 87.1%, while the threshold for the standard deviation of CHAR was 0.76 with a sensitivity of 77.3% and a specificity of 77.4%. The area under the curve (AUC) was 0.91 for mean value of CHAR while 0.78 for standard deviation of CHAR. Meanwhile, a contrast of AUC between CHAR and the former parameter we proposed showed CHAR had better performance in distinguishing PE (0.908 over 0.615, p < 0.01).

CONCLUSION

The novel parameter, CHAR, derived from PPG pulse wave differs in parturients with and without PE with high sensitivity and specificity, suggesting that the CHAR might be an effective tool in differentiating the presence of PE.

摘要

目的

描述比较分层面积比（CHAR），这是一种从光电容积脉搏波（PPG）导出的新参数，以及子痫前期（PE）患者和非子痫前期患者CHAR值的差异。

方法

在中国杭州浙江大学医学院附属妇产科医院对59例产妇（37例无PE，22例有PE）进行了研究。我们计算了从PPG脉搏波得出的CHAR值，并在有PE和无PE的产妇中进行比较。

结果

与无PE的产妇相比，有PE的产妇的CHAR值较低（p<0.01）。ROC分析表明，CHAR平均值预测PE的最佳阈值为7.92，灵敏度为86.4%，特异性为87.1%，而CHAR标准差的阈值为0.76，灵敏度为77.3%，特异性为77.4%。CHAR平均值的曲线下面积（AUC）为0.91，而CHAR标准差的AUC为0.78。同时，CHAR与我们之前提出的参数之间的AUC对比显示，CHAR在区分PE方面表现更好（0.908对0.615，p<0.01）。