Güdücü Çağdaş, Eskicioğlu Emre, Öz Didem, Öniz Adile, Çakmur Raif, Özgören Murat
Dokuz Eylül University, Faculty of Medicine, Department of Biophysics, 35340, Balcova, Izmir, Turkey.
Dokuz Eylül University, Faculty of Medicine, Department of Neurology, 35340, Balcova, Izmir, Turkey.
Neurosci Lett. 2019 May 14;701:170-174. doi: 10.1016/j.neulet.2019.02.039. Epub 2019 Feb 28.
Parkinson's Disease (PD) is a common neurodegenerative disorder affecting the function of dopaminergic cells in basal ganglia. Besides the motor symptoms, tremor, and dysfunction of sensory systems. In the literature, there was limited studies which investigates the basic sensorial processing in PD. Therefore, we aimed to establish the sensorial processing of simple auditory stimulations in naïve PD comparing to healthy controls (HC) via delta, theta, and alpha brain oscillatory responses. 12 naïve PD and 12 HC participated to the study. Brain responses recorded via the 64-channel electroencephalography (EEG) system in an electromagnetically and acoustically isolated room. The auditory stimuli (1500 Hz, 60 dB SPL, 500 ms) were delivered to the subjects via a headphone. The inter-stimulus interval was ranged between 2.5-4.5 s. The peak-to-peak maximum amplitudes were measured in the delta, theta and alpha frequency bands on 11 electrodes (including the frontal, central and parietal areas) for the statistical analysis in which one-way ANOVA test was employed for the comparisons between PD and HC. For the delta oscillatory responses, PD group has bigger amplitudes in frontal, central and parietal areas in comparison with HC. For the theta and alpha oscillatory responses, PD group has bigger amplitudes in parietal areas in comparison with HC. As a result, amplitudes of brain oscillatory responses in PD group were significantly bigger than the HC. In this context, decreased inhibitory mechanisms of cortical auditory processing due to the dysfunction of the dopaminergic activity may lead the increased evoked responses in PD group.
帕金森病（PD）是一种常见的神经退行性疾病，会影响基底神经节中多巴胺能细胞的功能。除了运动症状、震颤和感觉系统功能障碍外，文献中对PD患者基本感觉处理的研究有限。因此，我们旨在通过δ波、θ波和α波脑振荡反应，比较初发PD患者与健康对照者（HC）对简单听觉刺激的感觉处理情况。12名初发PD患者和12名HC参与了这项研究。在电磁和声学隔离的房间里，通过64通道脑电图（EEG）系统记录脑反应。听觉刺激（1500Hz，60dB SPL，500ms）通过耳机传递给受试者。刺激间隔在2.5 - 4.5秒之间。在11个电极（包括额叶、中央和顶叶区域）上测量δ波、θ波和α波频段的峰峰值最大振幅，用于统计分析，采用单因素方差分析检验比较PD组和HC组。对于δ波振荡反应，与HC相比，PD组在额叶、中央和顶叶区域的振幅更大。对于θ波和α波振荡反应，与HC相比，PD组在顶叶区域的振幅更大。结果，PD组的脑振荡反应振幅明显大于HC组。在这种情况下，多巴胺能活动功能障碍导致皮质听觉处理的抑制机制减弱，可能导致PD组的诱发电反应增加。
