突触小泡蛋白 2：分泌的多面调节蛋白。
Synaptic vesicle protein 2: A multi-faceted regulator of secretion.
机构信息
Department of Pharmacology, University of Washington, Seattle, WA, United States.
Department of Pharmacology, University of Washington, Seattle, WA, United States.
出版信息
Semin Cell Dev Biol. 2019 Nov;95:130-141. doi: 10.1016/j.semcdb.2019.02.003. Epub 2019 Mar 21.
Abstract
Synaptic Vesicle Protein 2 (SV2) comprises a recently evolved family of proteins unique to secretory vesicles that undergo calcium-regulated exocytosis. In this review we consider SV2s' structural features, evolution, and function and discuss its therapeutic potential as the receptors for an expanding class of drugs used to treat epilepsy and cognitive decline.
摘要
突触小泡蛋白 2（SV2）由一个最近进化的蛋白质家族组成，该家族特有的蛋白存在于分泌小泡中，这些小泡经历钙调节的胞吐作用。在这篇综述中，我们考虑了 SV2 的结构特征、进化和功能，并讨论了其作为一类不断扩大的用于治疗癫痫和认知能力下降的药物的受体的治疗潜力。
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