Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cytokine. 2019 May;117:65-71. doi: 10.1016/j.cyto.2019.02.003. Epub 2019 Feb 28.
Interleukins are cytokines involved in systemic inflammation and immune system regulation. Many studies have investigated the association between common genetic variations in interleukin-coding genes and COPD susceptibility. In this study, a systematic review and meta-analysis was performed to evaluate the association between interleukin gene variations and COPD pathogenesis. Association studies were retrieved from PubMed and Google Scholar databases using the standard systematic search strategy. A total of 26 different studies evaluating eight polymorphisms in four interleukin genes were included in this study. In overall comparisons, IL1β-rs16944, -rs1143627, -rs1143634, IL13-rs20541 polymorphisms were found not to be associated with the increased risk for developing COPD. However, IL1RN-rs2234663 and IL13-rs1800925 showed a strong association with COPD. We showed that the CC genotype carriers of the IL6-rs1800795 are at significantly higher risk of developing COPD (OR = 1.31, 95% CI: 1.04-1.64, P = 0.01) compared to GG carriers. In case of IL6-rs1800796, individuals with CC and CG genotypes showed a lower risk to develop COPD (OR = 0.46, 95%CI: 0.32-0.66, P > 0.00). This updated meta-analysis strongly supports the association of IL1RN-rs2234663, IL6-rs1800795, -rs1800795 and IL13-rs1800925 variants with COPD.
白细胞介素是参与全身炎症和免疫系统调节的细胞因子。许多研究已经调查了白细胞介素编码基因的常见遗传变异与 COPD 易感性之间的关系。在这项研究中，进行了系统评价和荟萃分析，以评估白细胞介素基因变异与 COPD 发病机制的关系。使用标准系统搜索策略从 PubMed 和 Google Scholar 数据库中检索关联研究。共有 26 项不同的研究评估了四个白细胞介素基因中的 8 个多态性，纳入了本研究。在总体比较中，IL1β-rs16944、-rs1143627、-rs1143634、IL13-rs20541 多态性与 COPD 发病风险增加无关。然而，IL1RN-rs2234663 和 IL13-rs1800925 与 COPD 有很强的关联。我们表明，IL6-rs1800795 的 CC 基因型携带者发生 COPD 的风险显著增加（OR=1.31，95%CI：1.04-1.64，P=0.01），与 GG 携带者相比。对于 IL6-rs1800796，CC 和 CG 基因型的个体发生 COPD 的风险较低（OR=0.46，95%CI：0.32-0.66，P>0.00）。这项更新的荟萃分析强烈支持 IL1RN-rs2234663、IL6-rs1800795、-rs1800795 和 IL13-rs1800925 变体与 COPD 之间的关联。
