CYP1A1基因多态性对慢性阻塞性肺疾病易感性的影响：一项荟萃分析
Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
作者信息
Wang Cheng-Di, Chen Nan, Huang Lin, Wang Jia-Rong, Chen Zhi-Yuan, Jiang Ya-Mei, He Ya-Zhou, Ji Yu-Lin
机构信息
Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
出版信息
Biomed Res Int. 2015;2015:942958. doi: 10.1155/2015/942958. Epub 2015 Sep 3.
OBJECTIVE
Several studies have evaluated the association between CYP1A1 polymorphisms and the susceptibility of chronic obstructive pulmonary disease (COPD) with inconclusive results. We performed the first comprehensive meta-analysis to summarize the association between CYP1A1 polymorphisms and COPD risk.
METHOD
A systematic literature search was conducted (up to April 2015) in five online databases: PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), WeiPu, and WanFang databases. The strength of association was calculated by odds ratio (OR) and corresponding 95% confidence interval (CI).
RESULTS
Seven case-control studies with 1050 cases and 1202 controls were included. Our study suggested a significant association between the MspI polymorphism and COPD risk (CC versus TC + TT: OR = 1.57, CI: 1.09-2.26, P = 0.02; CC versus TT: OR = 1.73, CI: 1.18-2.55, P = 0.005). For the Ile/Val polymorphism, a significant association with COPD risk was observed (GG versus AG + AA: OR = 2.75, CI: 1.29-5.84, P = 0.009; GG versus AA: OR = 3.23, CI: 1.50-6.93, P = 0.003; AG versus AA: OR = 1.39, CI: 1.01-1.90, P = 0.04). Subgroup analysis indicated a significant association between the MspI variation and COPD risk among Asians (CC versus TC + TT: OR = 1.70, CI: 1.06-2.71, P = 0.03; CC versus TT: OR = 1.84, CI: 1.11-3.06, P = 0.02).
CONCLUSION
The MspI and Ile/Val polymorphisms might alter the susceptibility of COPD, and MspI polymorphism might play a role in COPD risk among Asian population.
目的
多项研究评估了CYP1A1基因多态性与慢性阻塞性肺疾病（COPD）易感性之间的关联，但结果尚无定论。我们进行了首个综合性的荟萃分析，以总结CYP1A1基因多态性与COPD风险之间的关联。
方法
在五个在线数据库（PubMed、EMBASE、中国知网（CNKI）、维普和万方数据库）中进行了系统的文献检索（截至2015年4月）。采用比值比（OR）及相应的95%置信区间（CI）计算关联强度。
结果
纳入了7项病例对照研究，共1050例病例和1202例对照。我们的研究表明，MspI基因多态性与COPD风险之间存在显著关联（CC与TC + TT相比：OR = 1.57，CI：1.09 - 2.26，P = 0.02；CC与TT相比：OR = 1.73，CI：1.18 - 2.55，P = 0.005）。对于Ile/Val基因多态性，观察到与COPD风险存在显著关联（GG与AG + AA相比：OR = 2.75，CI：1.29 - 5.84，P = 0.009；GG与AA相比：OR = 3.23，CI：1.50 - 6.93，P = 0.003；AG与AA相比：OR = 1.39，CI：1.01 - 1.90，P = 0.04）。亚组分析表明，亚洲人群中MspI基因变异与COPD风险之间存在显著关联（CC与TC + TT相比：OR = 1.70，CI：1.06 - 2.
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