Manifold I H, Cole R, MacKintosh M, Smith W, Champion A E, Hancock B W
Eur J Surg Oncol. 1986 Mar;12(1):67-8.
A randomized double blind controlled trial has shown that topical, nitroglycerin vasodilator cream applied to the intended injection site in patients undergoing cytotoxic chemotherapy for various malignancies, produced detectable vasodilation and a decrease in minor aids to venepuncture compared to placebo. It did not decrease the number of attempts at cannulation needed nor the overall cannulation failure rate and cannot be recommended for general use in cytotoxic chemotherapy clinics.
一项随机双盲对照试验表明，对于接受各种恶性肿瘤细胞毒性化疗的患者，在预期注射部位涂抹局部硝酸甘油血管扩张剂乳膏，与安慰剂相比，可产生可检测到的血管扩张，并减少静脉穿刺的轻微辅助操作。它并未减少所需的插管尝试次数，也未降低总体插管失败率，因此不建议在细胞毒性化疗诊所普遍使用。
