Chryssikopoulos A
Geburtshilfe Frauenheilkd. 1986 Jan;46(1):48-51. doi: 10.1055/s-2008-1036162.
Three patients with Kallmann's syndrome (one of whom had undergone eight-year therapy with sex steroids) were studied with many dynamic tests. The progesterone and clomiphene tests were negative. An insulin test and TRH stimulation test showed a normal pool of GH and TSH in the hypophysis. A double stimulation with 100 micrograms LH-RH led to an inadequate gonadotropin response with a dominant FSH secretion, while the patient who had previously received sex steroids gave better results. The other two patients received 100 micrograms LH-RH i.m. daily for 20 days and the double LH-RH stimulation test was repeated. A satisfactory gonadotropin response with a predominance of LH secretion was noted. A TRH stimulation test revealed normal PRL secretion, while after a chlorpromazine test only one patient showed a satisfactory PRL secretion. Under combined HMG-HCG therapy, one of the patients conceived and had a normal outcome of her pregnancy.
对三名卡尔曼综合征患者（其中一名接受了八年的性类固醇治疗）进行了多项动态测试。孕酮和氯米芬试验均为阴性。胰岛素试验和促甲状腺激素释放激素（TRH）刺激试验显示垂体中生长激素（GH）和促甲状腺激素（TSH）储备正常。用100微克促黄体生成素释放激素（LH-RH）进行双重刺激导致促性腺激素反应不足，以促卵泡生成素（FSH）分泌为主，而之前接受过性类固醇治疗的患者结果较好。另外两名患者每天肌肉注射100微克LH-RH，共20天，然后重复进行双重LH-RH刺激试验。结果发现促性腺激素反应良好，以促黄体生成素（LH）分泌为主。TRH刺激试验显示催乳素（PRL）分泌正常，而在氯丙嗪试验后，只有一名患者的PRL分泌令人满意。在人绝经期促性腺激素（HMG）-人绒毛膜促性腺激素（HCG）联合治疗下，其中一名患者受孕且妊娠结局正常。
