Wijeratne Nilika, Tate Jillian R, Toit Stephen Du, Smith Joel D, Soepnel Andrew, Choy Kay Weng, Martin Helen, Henry Robyn, Glegg Kaye, Byrnes Elizabeth, Wienholt Louise, Mollee Peter
Chemical Pathology, Dorevitch Pathology, Heidelberg, Vic. 3084, Australia.
Monash Pathology, Monash Health, Clayton, Vic. 3168, Australia.
Clin Biochem Rev. 2019 Feb;40(1):43-54.
Quantification of co-migrating paraproteins in the beta-region presents an ongoing challenge for laboratories performing serum protein electrophoresis. The between-laboratory variation may impact patient care if the patient uses different pathology services during plasma cell dyscrasia monitoring. To identify the practical difficulties and determine the extent of agreement in the reporting of beta-migrating paraproteins in Australia and New Zealand (NZ), sample exchanges were conducted in five Australian states and in NZ in early 2018. This study has highlighted the variation in quantification and reporting of beta-migrating paraproteins which could potentially affect patient monitoring and management.
对进行血清蛋白电泳的实验室而言，定量分析β区共迁移的副蛋白一直是一项挑战。如果患者在浆细胞异常增殖症监测期间使用不同的病理服务，实验室间的差异可能会影响患者护理。为了确定实际困难，并确定澳大利亚和新西兰（NZ）在报告β迁移副蛋白方面的一致程度，2018年初在澳大利亚的五个州和新西兰进行了样本交换。这项研究突出了β迁移副蛋白在定量和报告方面的差异，这可能会对患者监测和管理产生潜在影响。
