Foresta C, Manoni F, Businaro V, Donadel C, Indino M, Scandellari C
J Androl. 1986 Mar-Apr;7(2):77-82. doi: 10.1002/j.1939-4640.1986.tb00883.x.
Human seminal plasma contains large amounts of transferrin, which is a protein secreted mostly by Sertoli cells. It has been suggested that the concentration of transferrin may serve as a possible clinical marker of Sertoli cell function. Therefore the concentration of this protein in human seminal plasma from fertile and infertile men has been evaluated in order to find a relationship between transferrin concentrations and human semen parameters and plasma FSH levels. Findings show that seminal transferrin in subjects with oligozoospermia or azoospermia is significantly lower than in controls, and that it is strongly related to sperm count. Results also indicate that transferrin secretion can be impaired when plasma FSH levels are still normal, suggesting that seminal transferrin is an early and specific marker of Sertoli cell function. These results, however, do not clarify whether impairment of transferrin secretion by Sertoli cells is due to an organic dysfunction or to an organic secretory alteration.
人类精浆含有大量转铁蛋白，它是一种主要由支持细胞分泌的蛋白质。有人提出，转铁蛋白浓度可能作为支持细胞功能的一种潜在临床标志物。因此，对来自生育男性和不育男性的人类精浆中这种蛋白质的浓度进行了评估，以寻找转铁蛋白浓度与人类精液参数及血浆促卵泡激素（FSH）水平之间的关系。研究结果表明，少精子症或无精子症患者的精浆转铁蛋白明显低于对照组，且与精子计数密切相关。结果还表明，当血浆FSH水平仍正常时，转铁蛋白分泌可能受损，这表明精浆转铁蛋白是支持细胞功能的早期特异性标志物。然而，这些结果并未阐明支持细胞转铁蛋白分泌受损是由于器质性功能障碍还是器质性分泌改变。
