Orlando C, Caldini A L, Barni T, Wood W G, Strasburger C J, Natali A, Maver A, Forti G, Serio M
Fertil Steril. 1985 Feb;43(2):290-4. doi: 10.1016/s0015-0282(16)48388-3.
Transferrin and ceruloplasmin have been measured by a solid-phase chemiluminescent method in seminal fluid and circulating blood of normal and vasectomized subjects (1 year after operation). This study has confirmed that approximately 80% of seminal transferrin comes from the testis, while seminal ceruloplasmin was not found different in the two groups. In patients affected by azoospermia due to seminiferous tubular damage (n = 15) in whom an obstruction was previously excluded, seminal transferrin was always below the normal range. On the contrary, seminal ceruloplasmin was always in the normal range, and circulating follicle-stimulating hormone was found above the normal range only in nine cases. No correlation was found between seminal transferrin and circulating follicle-stimulating hormone in such groups. In an unselected group of infertile patients with decreased sperm concentration and/or sperm motility, seminal transferrin was found correlated with the sperm count. These studies seem to suggest that seminal transferrin is a reliable index of seminiferous tubular function.
采用固相化学发光法检测了正常受试者和输精管结扎术后1年受试者的精液及循环血液中的转铁蛋白和铜蓝蛋白。本研究证实，约80%的精液转铁蛋白来自睾丸，而两组的精液铜蓝蛋白未发现差异。在因生精小管损伤导致无精子症的患者（n = 15）中，先前已排除梗阻因素，其精液转铁蛋白始终低于正常范围。相反，精液铜蓝蛋白始终在正常范围内，仅9例患者的循环促卵泡激素高于正常范围。在这些组中，未发现精液转铁蛋白与循环促卵泡激素之间存在相关性。在一组未经过挑选的精子浓度和/或精子活力降低的不育患者中，发现精液转铁蛋白与精子计数相关。这些研究似乎表明，精液转铁蛋白是生精小管功能的可靠指标。
