Wu Qi, Zhao Wanlong, Chen Gangling, Su Xue, Li Rong
State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Longmian Road, Nanjing, Jiangsu, PR China.
Shanghai Qingpu Institute for Food and Drug Control, Shanghai, China.
Pak J Pharm Sci. 2019 Jan;32(1(Supplementary)):261-268.
Using rat thoracic aortic rings to test the relaxing effects of the 95% ethanol extract and aqueous extract of Taohong Siwu decoction (THSW) on endothelium intact or endothelium removed aortic rings. Results showed that the 95% ethanol extract (0.1, 1, 10, 100, 1000 mg•L) and aqueous extract (0.1, 1, 10, 100, 1000 mg•L) of THSW were able to relax the intact endothelium aortic rings pre-contracted by 10 mol•L PE. 10 mol•L L-NAME and 10 mol•L methylene blue both were able to inhibit the relaxation other than indomethacin. For the endothelium removed aortic rings, potassium channel blocker 3×10mol•L tetraethylammonium chloride and 10 mol•L glibenclamide had no effect on the relaxation effects caused by the 95% ethanol extract and aqueous extract of THSW. It could be concluded that the 95% ethanol extract and aqueous extract of THSW relax blood vessel by endothelium-dependent way.
采用大鼠胸主动脉环，检测桃红四物汤（THSW）95%乙醇提取物和水提取物对内皮完整或去内皮主动脉环的舒张作用。结果显示，THSW的95%乙醇提取物（0.1、1、10、100、1000 mg•L）和水提取物（0.1、1、10、100、1000 mg•L）能够舒张由10 μmol•L去氧肾上腺素（PE）预收缩的内皮完整主动脉环。10 μmol•L左旋硝基精氨酸甲酯（L-NAME）和10 μmol•L亚甲蓝均能抑制舒张作用，而吲哚美辛无此作用。对于去内皮主动脉环，钾通道阻滞剂3×10 μmol•L四乙铵氯化物和10 μmol•L格列本脲对THSW 95%乙醇提取物和水提取物所致的舒张作用无影响。可以得出结论，THSW的95%乙醇提取物和水提取物通过内皮依赖性方式舒张血管。
