• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

桃红四物汤联合降压药治疗高血压的疗效：Meta 分析。

The effect of Taohong Siwu decoction combined with antihypertensive medicine in the treatment of hypertension: Meta-analysis.

机构信息

School of Traditional Chinese Medicine of Jinan University, Guangzhou, China.

出版信息

Medicine (Baltimore). 2022 Dec 9;101(49):e32133. doi: 10.1097/MD.0000000000032133.

DOI:10.1097/MD.0000000000032133
PMID:36626486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9750686/
Abstract

BACKGROUND

Taohong Siwu Decoction (THSWD) is a classic prescription of traditional Chinese medicine. Recent research has shown that the practical components of THSWD have specific curative effects on various cardiovascular diseases, including hypertension, suggesting THSWD could effectively lower blood pressure (BP) with fewer side effects. However, little information is available regarding the effectiveness of THSWD combined with antihypertensive medicine on hypertension.

OBJECTIVE

This meta-analysis aimed to study the efficacy and safety of THSWD in treating hypertension.

METHODS

According to the search strategy, 8 databases were searched, including China Knowledge Network (CNKI), Wanfang Database, VIP Database, Pubmed, China Biomedical Literature Database (CBM), web of science, EMBASE and Cochrane Library, for the randomized controlled trial of THSWD on hypertension. 9 RCTs were included and 827 patients were involved. This meta-analysis used RevMan 5.4 to evaluate the articles.

RESULTS

This review included 9 RCTs. All studies were THSWD with the antihypertensive drug compared with single antihypertensive western medicine. The total effective rate of THSWD combined with corresponding western medicine was significantly improved (Relative risk = 1.26; 95% CI: 1.16-1.37, P < .00001), which could effectively reduce the systolic BP (MD = -15.28 mm Hg; 95% CI: -20.17 to -10.40, P < .00001=, diastolic BP (MD = -9.70 mm Hg; 95% CI: -12.66 to -6.73, P < .00001), Triglycerides (MD = -1.48, 95%CI: -2.09 to -0.87, P < .00001), total cholesterol (MD = -1.43, 95% CI: -1.63 to -1.24, P < .00001) and low density lipoprotein cholesterol (MD = -0.93, 95% CI: -1.07 to -0.80, P < .00001). Compared with the single routine western medicine group, THSWD combined with the corresponding western medicine increased serum high-density lipoprotein (MD = 0.41, 95% CI: 0.35 to 0.46, P < .00001).

CONCLUSION

THSWD combined with antihypertensive drugs in treating hypertension was curative in lowering BP, improving blood lipid levels and reducing the incidence of adverse reactions compared to antihypertensive medications treatment. However, more high-quality studies are needed due to the biased results and the small number of studies for further verification of the effectiveness of THSWD, and providing a new treatment for clinical reference.

摘要

背景

桃红四物汤（THSWD）是一种经典的中药方剂。最近的研究表明，THSWD 的实际成分对各种心血管疾病，包括高血压，具有特定的疗效，这表明 THSWD 可以有效地降低血压（BP），且副作用较少。然而，关于 THSWD 与降压药联合治疗高血压的疗效信息很少。

目的

本荟萃分析旨在研究 THSWD 治疗高血压的疗效和安全性。

方法

根据搜索策略，检索了 8 个数据库，包括中国知网（CNKI）、万方数据库、维普数据库、PubMed、中国生物医学文献数据库（CBM）、Web of Science、EMBASE 和 Cochrane 图书馆，以获取关于 THSWD 治疗高血压的随机对照试验。共纳入 9 项 RCT，涉及 827 例患者。本荟萃分析使用 RevMan 5.4 对文章进行评估。

结果

本综述纳入了 9 项 RCT。所有研究均为 THSWD 联合降压西药与单纯降压西药的比较。THSWD 联合相应西药的总有效率明显提高（相对风险=1.26；95%CI：1.16-1.37，P<0.00001），可有效降低收缩压（MD=-15.28mmHg；95%CI：-20.17 至-10.40，P<0.00001）、舒张压（MD=-9.70mmHg；95%CI：-12.66 至-6.73，P<0.00001）、三酰甘油（MD=-1.48；95%CI：-2.09 至-0.87，P<0.00001）、总胆固醇（MD=-1.43；95%CI：-1.63 至-1.24，P<0.00001）和低密度脂蛋白胆固醇（MD=-0.93；95%CI：-1.07 至-0.80，P<0.00001）。与单纯常规西药组相比，THSWD 联合相应西药可提高血清高密度脂蛋白（MD=0.41；95%CI：0.35 至 0.46，P<0.00001）。

结论

与降压药物治疗相比，THSWD 联合降压药物治疗高血压在降低血压、改善血脂水平和降低不良反应发生率方面具有疗效。然而，由于结果存在偏倚，且研究数量较少，需要更多高质量的研究进一步验证 THSWD 的有效性，为临床提供新的治疗参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/cb5ceffc56d9/medi-101-e32133-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/3309d7f31c0e/medi-101-e32133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/03e6d0d024af/medi-101-e32133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/b441514e623b/medi-101-e32133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/144813ddfeea/medi-101-e32133-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/e87437b2a090/medi-101-e32133-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/1cfb747f459e/medi-101-e32133-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/cb5ceffc56d9/medi-101-e32133-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/3309d7f31c0e/medi-101-e32133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/03e6d0d024af/medi-101-e32133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/b441514e623b/medi-101-e32133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/144813ddfeea/medi-101-e32133-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/e87437b2a090/medi-101-e32133-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/1cfb747f459e/medi-101-e32133-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01f0/9750686/cb5ceffc56d9/medi-101-e32133-g007.jpg

相似文献

1
The effect of Taohong Siwu decoction combined with antihypertensive medicine in the treatment of hypertension: Meta-analysis.桃红四物汤联合降压药治疗高血压的疗效：Meta 分析。
Medicine (Baltimore). 2022 Dec 9;101(49):e32133. doi: 10.1097/MD.0000000000032133.
2
Effectiveness of Taohong Siwu decoction in the prevention of deep vein thrombosis in hip surgery patients: A systematic review and meta-analysis of randomized controlled trials.桃红四物汤预防髋关节手术患者深静脉血栓形成的有效性：系统评价和随机对照试验的荟萃分析。
Medicine (Baltimore). 2024 Mar 1;103(9):e37241. doi: 10.1097/MD.0000000000037241.
3
The effect of Chinese herbal medicine Jian Ling Decoction for the treatment of essential hypertension: a systematic review.中药健灵汤治疗原发性高血压的疗效：系统评价。
BMJ Open. 2015 Feb 4;5(2):e006502. doi: 10.1136/bmjopen-2014-006502.
4
Integrated Chinese herbal medicine with Western Medicine versus Western Medicine in the effectiveness of primary hypertension treatment: A systematic review and meta-analysis of randomized controlled trials.中西医结合与单纯西医治疗原发性高血压的疗效比较：一项随机对照试验的系统评价和荟萃分析
J Ethnopharmacol. 2023 Jan 10;300:115703. doi: 10.1016/j.jep.2022.115703. Epub 2022 Sep 10.
5
The effect of Chinese herbal medicine combined with western medicine on vascular endothelial function for patients with hypertension: Protocol for a systematic review and meta-analysis.中药联合西药对高血压患者血管内皮功能的影响：系统评价与Meta分析方案
Medicine (Baltimore). 2019 Dec;98(49):e18134. doi: 10.1097/MD.0000000000018134.
6
Meta-analysis of the effectiveness of traditional Chinese herbal formula Zhen Wu Decoction for the treatment of hypertension.中药方剂真武汤治疗高血压有效性的Meta分析
BMJ Open. 2015 Dec 11;5(12):e007291. doi: 10.1136/bmjopen-2014-007291.
7
[Meta-analysis for clinical efficacy of traditional Chinese medicine in treating resistant hypertension].[中医药治疗顽固性高血压临床疗效的Meta分析]
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(3):685-693. doi: 10.19540/j.cnki.cjcmm.20200521.501.
8
Songling Xuemaikang Capsule () for primary hypertension: A systematic review of randomized controlled trials.松龄血脉康胶囊治疗原发性高血压：随机对照试验的系统评价
Chin J Integr Med. 2015 Apr;21(4):312-20. doi: 10.1007/s11655-014-1709-6. Epub 2014 Mar 2.
9
Chinese herbal medicine for resistant hypertension: a systematic review.用于治疗顽固性高血压的中草药：一项系统评价
BMJ Open. 2015 Jan 30;5(1):e005355. doi: 10.1136/bmjopen-2014-005355.
10
[Systematic evaluation and trail sequential analysis of efficacy and safety of Yangxue Qingnao Granules in treatment of essential hypertension and its accompanying symptoms].[养血清脑颗粒治疗原发性高血压及其伴随症状的疗效与安全性的系统评价和序贯分析]
Zhongguo Zhong Yao Za Zhi. 2021 Mar;46(6):1523-1536. doi: 10.19540/j.cnki.cjcmm.20200712.501.

引用本文的文献

1
Pharmacological and toxicological effects of Jiangfangbaoxin and determination of its components in the blood of spontaneously hypertensive rats.降压保心片的药理毒理作用及其在自发性高血压大鼠血液中成分的测定
Sci Rep. 2025 Feb 10;15(1):4934. doi: 10.1038/s41598-025-88009-0.
2
The Cardioprotective Potential of Herbal Formulas in Myocardial Infarction-Induced Heart Failure through Inhibition of JAK/STAT3 Signaling and Improvement of Cardiac Function.中药复方通过抑制JAK/STAT3信号通路和改善心功能对心肌梗死所致心力衰竭的心脏保护作用
Pharmaceuticals (Basel). 2024 Aug 27;17(9):1132. doi: 10.3390/ph17091132.
3
Research Progress on the Correlation Between Hypertension and Gut Microbiota.

本文引用的文献

1
Traditional Chinese Medicine for Essential Hypertension: A Clinical Evidence Map.用于原发性高血压的中医：一项临床证据图谱
Evid Based Complement Alternat Med. 2020 Dec 18;2020:5471931. doi: 10.1155/2020/5471931. eCollection 2020.
2
Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review.脂肪酸结合蛋白在心血管疾病中的作用：一项系统评价。
J Clin Med. 2020 Oct 22;9(11):3390. doi: 10.3390/jcm9113390.
3
Aging and plasma triglyceride metabolism.衰老与血浆甘油三酯代谢。
高血压与肠道微生物群相关性的研究进展
J Multidiscip Healthc. 2024 May 16;17:2371-2387. doi: 10.2147/JMDH.S463880. eCollection 2024.
4
Researching the molecular mechanisms of Taohong Siwu Decoction in the treatment of varicocele-associated male infertility using network pharmacology and molecular docking: A review.采用网络药理学和分子对接技术研究桃红四物汤治疗精索静脉曲张相关男性不育的分子机制：综述。
Medicine (Baltimore). 2023 Aug 4;102(31):e34476. doi: 10.1097/MD.0000000000034476.
J Lipid Res. 2020 Aug;61(8):1161-1167. doi: 10.1194/jlr.R120000922. Epub 2020 Jun 25.
4
Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension.网络药理学揭示桃红四物汤治疗原发性高血压的作用机制。
Med Sci Monit. 2020 Mar 18;26:e920682. doi: 10.12659/MSM.920682.
5
2019 Chinese guideline for the management of hypertension in the elderly.《2019 中国老年高血压管理指南》
J Geriatr Cardiol. 2019 Feb;16(2):67-99. doi: 10.11909/j.issn.1671-5411.2019.02.001.
6
Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway.桃红四物汤对大鼠离体主动脉环的相关作用依赖于内皮一氧化氮-cGMP途径。
Pak J Pharm Sci. 2019 Jan;32(1(Supplementary)):261-268.
7
The Interplay Between Cholesterol Metabolism and Intrinsic Ageing.胆固醇代谢与内在衰老之间的相互作用
Subcell Biochem. 2018;90:99-118. doi: 10.1007/978-981-13-2835-0_4.
8
2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension.2018年欧洲心脏病学会/欧洲高血压学会动脉高血压管理指南：欧洲心脏病学会动脉高血压管理特别工作组和欧洲高血压学会：欧洲心脏病学会动脉高血压管理特别工作组和欧洲高血压学会。
J Hypertens. 2018 Oct;36(10):1953-2041. doi: 10.1097/HJH.0000000000001940.
9
Status of Hypertension in China: Results From the China Hypertension Survey, 2012-2015.中国高血压现状：2012-2015 年中国高血压调查结果。
Circulation. 2018 May 29;137(22):2344-2356. doi: 10.1161/CIRCULATIONAHA.117.032380. Epub 2018 Feb 15.
10
Urinary metabolomics study the mechanism of Taohong Siwu Decoction intervention in acute blood stasis model rats based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.基于液相色谱-四极杆飞行时间质谱联用技术的尿代谢组学研究桃红四物汤对急性血瘀模型大鼠的干预机制
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 1;1074-1075:51-60. doi: 10.1016/j.jchromb.2017.12.035. Epub 2018 Jan 2.