Rozanski Verena, Laux Gerd, Schwarz Johannes
Department of Neurology, Technical University of Munich, Munich.
Clin Neuropharmacol. 2019 May/Jun;42(3):77-79. doi: 10.1097/WNF.0000000000000332.
Drug-induced Parkinsonism (DIP) represents the second most-frequent etiology of Parkinson syndromes after neurodegenerative disorders. It has been described mainly for antipsychotics, Ca-channel blockers, antiemetics, and gastrointestinal prokinetics. In this article, we present a clinical case series of 10 patients, retrieved within our movement disorders hospital, with DIP under intake of opipramol. Symptoms completely resolved after drug withdrawal, and associated risk factors were old age, high doses, and presence of cortical atrophy. This frequently prescribed anxiolytic drug has so far not been associated with DIP. Our objective is to raise awareness of DIP as an adverse effect of opipramol.
药物性帕金森综合征（DIP）是继神经退行性疾病之后帕金森综合征的第二大常见病因。主要在抗精神病药物、钙通道阻滞剂、止吐药和胃肠促动力药使用中被描述。在本文中，我们展示了在我们的运动障碍医院检索到的10例服用奥匹哌醇后出现DIP的临床病例系列。停药后症状完全缓解，相关危险因素为老年、高剂量和存在皮质萎缩。这种经常使用的抗焦虑药物迄今为止尚未与DIP相关联。我们的目的是提高对奥匹哌醇不良反应导致DIP的认识。
