Yap P L, McClelland D B
J Infect. 1986 Jan;12(1):5-10. doi: 10.1016/s0163-4453(86)94717-1.
In an open study, three different immunoglobulin preparations for intravenous use (IV IgG), namely pH4 and pepsin treated immunoglobulin ('Sandoglobulin'); reduced and alkylated immunoglobulin ('Gamimune') as well as ultrafiltered, pH4 and pepsin treated immunoglobulin manufactured by the Scottish National Blood Transfusion Service ('SNBTS IV IgG'), were compared with intramuscular immunoglobulin (IM IgG) in five patients with primary hypogammaglobulinaemia, by treating each patient consecutively with each immunoglobulin preparation for 3 months. Few adverse reactions were noted with any of the intravenous immunoglobulin preparations and these mainly consisted of mild fever (less than 38 degrees C). Concentrations of serum IgG were higher with all intravenous immunoglobulin preparations compared with IM IgG. Furthermore, all the patients preferred IV to IM IgG therapy. As higher doses of immunoglobulin are associated with a reduction in infections in hypogammaglobulinaemic patients, we conclude that intravenous immunoglobulin therapy should be considered for the prophylaxis of infection in patients with primary hypogammaglobulinaemia.
在一项开放性研究中，将三种不同的静脉用免疫球蛋白制剂（静脉注射免疫球蛋白G），即pH4和经胃蛋白酶处理的免疫球蛋白（“Sandoglobulin”）；还原和烷基化免疫球蛋白（“Gamimune”）以及由苏格兰国家输血服务中心生产的超滤、pH4和经胃蛋白酶处理的免疫球蛋白（“SNBTS静脉注射免疫球蛋白G”），与肌肉注射免疫球蛋白（肌肉注射免疫球蛋白G）在5例原发性低丙种球蛋白血症患者中进行比较，每位患者依次接受每种免疫球蛋白制剂治疗3个月。使用任何一种静脉注射免疫球蛋白制剂时均未观察到严重不良反应，主要为低热（低于38摄氏度）。与肌肉注射免疫球蛋白G相比，所有静脉注射免疫球蛋白制剂的血清免疫球蛋白G浓度均更高。此外，所有患者均更倾向于静脉注射免疫球蛋白G治疗而非肌肉注射免疫球蛋白G治疗。由于更高剂量的免疫球蛋白与低丙种球蛋白血症患者感染率降低相关，我们得出结论，对于原发性低丙种球蛋白血症患者的感染预防应考虑采用静脉注射免疫球蛋白治疗。
