Goryachkin A M, Sysolyatin P G, Cherdantseva L A, Potapova O V, Beklemishev A B, Baydik O D
Novosibirsk State Medical University, Novosibirsk, Russia.
Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
Stomatologiia (Mosk). 2019;98(1):34-37. doi: 10.17116/stomat20199801134.
The aim of the study was to study the effect of the gel on the basis of recombinant human angiogenin on the rate of regeneration of donor palatal wounds. The study involved 20 patients (8 men and 12 women) aged 32 to 55 years. Patients were divided into two groups: the 1 group is a study group (n=10), whose patients in the postoperative period used a gel based on recombinant human angiogenin, the 2 group is a control group (n=10) in which a gel based on recombinant human angiogenin was not used. Patients in both study groups underwent vestibuloplasty with simultaneous plasty of the attached keratinized gingiva with a free gingival graft from the area of the hard palate. The operations were carried out at the stage of disclosing dental implants, simultaneously with the installation of healing abatements or 4 weeks before dental implantation. For histological examination, tissue samples were obtained from the region of the edge of the donor's wounds of the palate at the 7 and 14 days after surgery. As a result of the study, significant differences were found in the comparison groups when assessing the processes of inflammation, angiogenesis and epithelization. The local application of the gel containing recombinant human angiogenin resulted in a rapid decrease in the intensity of inflammation in lamina propria mucosae and a significant decrease in the bulk density of cell infiltrates, accelerating regeneration. This is primarily due to the stimulation of the development of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and increased blood supply to the affected area, as well as an increase in the proportion of fibroblasts. The most important observation was the increase in the rate of epithelialization of donor wounds of the hard palate.
本研究的目的是研究基于重组人血管生成素的凝胶对供体腭部伤口再生速率的影响。该研究纳入了20例年龄在32至55岁之间的患者（8名男性和12名女性）。患者被分为两组：第1组为研究组（n = 10），其患者在术后使用基于重组人血管生成素的凝胶；第2组为对照组（n = 10），该组患者未使用基于重组人血管生成素的凝胶。两个研究组的患者均接受了前庭成形术，同时采用来自硬腭区域的游离龈瓣对附着角化龈进行成形术。手术在暴露牙种植体阶段进行，与安装愈合帽同时进行或在牙种植术前4周进行。为进行组织学检查，在术后第7天和第14天从腭部供体伤口边缘区域获取组织样本。研究结果显示，在评估炎症、血管生成和上皮形成过程时，比较组之间存在显著差异。局部应用含重组人血管生成素的凝胶可导致固有层黏膜炎症强度迅速降低，细胞浸润的体积密度显著降低，从而加速再生。这主要是由于表皮生长因子（EGF）、血管内皮生长因子（VEGF）的发育受到刺激，受影响区域的血液供应增加，以及成纤维细胞比例增加。最重要的观察结果是硬腭供体伤口的上皮形成速率增加。
