[缺血性中风的细胞治疗。俄罗斯联邦的临床试验结果及临床应用前景]

[Cell therapy for ischemic stroke. Results of clinical trials and perspectives of clinical application in the Russian Federation].

作者信息

Namestnikova D D, Tairova R T, Cherkashova E A, Sukhinich K K, Gubskiy I L, Gubskiy L V, Yarygin K N

机构信息

Pirogov Russian National Research Medical University, Moscow, Russia.

Federal Center of Cererbrovascular Pathology and Stroke, Pirogov Russian National Research Medical University, Moscow, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12. Vyp. 2):94-104. doi: 10.17116/jnevro201811812294.

DOI:10.17116/jnevro201811812294

PMID:30830124

Abstract

The first part of the review summarized the results of preclinical animal studies using stroke models that demonstrated the efficacy of cell therapy. The second part presents the proposed mechanisms of action of stem cells, optimal therapeutic window for cell transplantation, the results of completed clinical trials on humans in the period from 2010 to 2017, as well as the legal aspects of the use of cell technologies in the Russian Federation.

摘要

综述的第一部分总结了使用中风模型的临床前动物研究结果，这些研究证明了细胞疗法的有效性。第二部分介绍了干细胞的作用机制、细胞移植的最佳治疗窗口、2010年至2017年期间已完成的人体临床试验结果，以及俄罗斯联邦使用细胞技术的法律方面。