Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Metallomics. 2019 Mar 20;11(3):676-685. doi: 10.1039/c8mt00331a.
76 pregnant women, among them 38 affected by gestational diabetes mellitus (GDM) and 38 control subjects, were recruited at the University Hospital of Padua (Italy). Placenta samples, maternal whole blood and umbilical cord whole blood were collected after delivery and analysed via ICP-MS to determine the metallome, i.e. the whole elemental content. Results were statistically evaluated to evidence the correlation between the elemental concentrations in all samples and the presence of the disease. The results obtained in whole cord blood showed that many elements were correlated with GDM: Ca, Cu, Na, and Zn were present in higher concentration in GDM cord blood than in control samples, whereas Fe, K, Mn, P, Rb, S and Si showed an opposite trend. It was also highlighted that the cord blood from GDM patients exhibited an elemental composition more similar to that of the mother blood compared with the cord blood from control subjects. These results, in part interpreted in the light of the literature, open the possibility to use cord blood as a GDM marker, thus helping to delineate more accurate nutritional guidelines for pregnant women and to explain the biochemical processes occurring in the fetus and placenta during GDM.
76 名孕妇，其中 38 名为妊娠期糖尿病（GDM）患者，38 名为对照组，在意大利帕多瓦大学医院招募。分娩后采集胎盘样本、产妇全血和脐血全血，并通过 ICP-MS 进行分析，以确定金属组学，即全元素含量。对结果进行统计学评估，以证明所有样本中元素浓度与疾病存在之间的相关性。在整个脐血中获得的结果表明，许多元素与 GDM 相关：GDM 脐血中的 Ca、Cu、Na 和 Zn 浓度高于对照组，而 Fe、K、Mn、P、Rb、S 和 Si 则呈现相反的趋势。还强调了与对照组相比，GDM 患者的脐血中的元素组成与母亲的血液更为相似。这些结果，部分根据文献进行解释，为使用脐血作为 GDM 标志物提供了可能性，从而有助于为孕妇制定更精确的营养指南，并解释 GDM 期间胎儿和胎盘发生的生化过程。
