Roverso Marco, Berté Chiara, Di Marco Valerio, Lapolla Annunziata, Badocco Denis, Pastore Paolo, Visentin Silvia, Cosmi Erich
Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Metallomics. 2015 Jul;7(7):1146-54. doi: 10.1039/c5mt00050e.
Obtaining the knowledge of the "omics" and therefore of the metallomics of gestational diabetes mellitus (GDM) appears to be a necessary task to obtain information about the molecular causes of this disease. In this study, the metallome of GDM and of other types of diabetes mellitus was first reviewed. The comparative analysis of the published data revealed that no GDM elemental markers could be identified with sufficient reliability in blood or in the other considered samples, with the partial exception of selenium. The placenta was chosen as an alternative target organ for the analysis of the GDM metallome. The full elemental average composition of 19 healthy placentas was obtained by ICP-MS. Analyses were then performed on 28 placentas from women affected by GDM. The statistical tests and the principal component analysis evidenced that cadmium was found in lower concentrations and selenium was found in higher concentrations in GDM placentas than in those of the control group. These results were interpreted in light of literature data, and they attract attention on two key elements for understanding the molecular pathways of GDM.
获取“组学”知识，进而了解妊娠期糖尿病（GDM）的金属组学，似乎是获取有关该疾病分子病因信息的一项必要任务。在本研究中，首先对GDM和其他类型糖尿病的金属组进行了综述。对已发表数据的比较分析表明，在血液或其他所考虑的样本中，无法足够可靠地鉴定出GDM元素标志物，硒仅为例外。胎盘被选为分析GDM金属组的替代靶器官。通过电感耦合等离子体质谱法（ICP-MS）获得了19个健康胎盘的完整元素平均组成。然后对28个受GDM影响的女性的胎盘进行了分析。统计检验和主成分分析表明，与对照组相比，GDM胎盘中镉的浓度较低，而硒的浓度较高。这些结果根据文献数据进行了解释，它们引起了人们对理解GDM分子途径的两个关键元素的关注。
