State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing, 100191, China.
Angew Chem Int Ed Engl. 2019 Apr 23;58(18):6074-6078. doi: 10.1002/anie.201900199. Epub 2019 Mar 28.
We report for the first time that the benzofuro[3,2-b]indoline framework could be obtained by PIDA-mediated direct oxidative coupling of 2,3-disubstituted-indoles with phenols. Application of this chemistry allows for an eight-step total synthesis of phalarine from commercially available tryptamine.
我们首次报道了通过 PIDA 介导的 2,3-取代吲哚与酚的直接氧化偶联反应可以得到苯并呋喃[3,2-b]吲哚啉骨架。该化学方法的应用可以从商业可得的色胺出发，经过八步总合成得到麦角灵。
