Bougle D, Pepin D, Delhaye M, Chambaz J, Ricour C
JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):216-9. doi: 10.1177/0148607186010002216.
In order to prevent essential fatty acid (EFA) deficiency induced by fat-free total parenteral nutrition (TPN), 10 infants on TPN were rubbed three times daily for 20 days using oenethera oil (80% EFA). Total EFA amount provided cutaneously was 1900 mg/kg/d. Plasma and red blood cells phospholipids were determined on days 1 and 20 in these 10 treated and six untreated infants on TPN and compared with those of normal control infants. On day 1, plasma nonessential FA including 20:3 n-9(p less than 0.01) were increased in both TPN groups while 18:2 n-6 and 18:3 n-3 (p less than 0.001 and p less than 0.01) were decreased. On the 20th day, EFA deficiency had worsened with a decrease in plasma level of 20:4 n-6 (p less than 0.02) and a higher than normal triene/tetraene ratio : 3.4 +/- 1.1 and 2.3 +/- 0.6 vs 0.1 +/- 0.1 (p less than 0.02). As for red blood cells phospholipids, 16:0 was increased and 18:2 n-6 and 20:3 n-6 were decreased (p less than 0.05) on day 1. On day 20, these FA were more abnormal while 20:3 n-9 became significantly increased (p less than 0.05). No difference was observed between the TPN groups at any time. These results show that cutaneous application of large amounts of EFA-rich oil is unable to prevent or cure TPN induced EFA deficiency.
为预防无脂全胃肠外营养（TPN）所致的必需脂肪酸（EFA）缺乏，对10例接受TPN的婴儿每日3次涂抹月见草油（含80% EFA），共20天。经皮肤提供的EFA总量为1900 mg/kg/d。在第1天和第20天对这10例接受治疗的以及6例未接受治疗的TPN婴儿测定血浆和红细胞磷脂，并与正常对照婴儿的进行比较。第1天，两个TPN组血浆非必需脂肪酸包括20:3 n-9（p<0.01）均升高，而18:2 n-6和18:3 n-3（p<0.001和p<0.01）降低。第20天，EFA缺乏加重，20:4 n-6血浆水平降低（p<0.02），且三烯/四烯比值高于正常：分别为3.4±1.1和2.3±0.6，而正常对照为0.1±0.1（p<0.02）。至于红细胞磷脂，第1天16:0升高，18:2 n-6和20:3 n-6降低（p<0.05）。第20天，这些脂肪酸更为异常，而20:3 n-9显著升高（p<0.05）。两个TPN组在任何时间均未观察到差异。这些结果表明，经皮肤大量涂抹富含EFA的油不能预防或治愈TPN所致的EFA缺乏。
