Lee E J, Gibson R A, Simmer K
Department of Paediatrics and Child Health, Flinders Medical Centre, Bedford Park, South Australia.
Arch Dis Child. 1993 Jan;68(1 Spec No):27-8. doi: 10.1136/adc.68.1_spec_no.27.
The topical application of vegetable oil was assessed as an alternative means of providing essential fatty acids (EFA) to parentally fed preterm infants who were not receiving lipid. Three infant pairs ranging in gestational age from 26-32 weeks were studied. Safflower oil or safflower oil esters (1 g linoleic acid/kg/day) were applied to available areas daily. All infants rapidly developed biochemical EFA deficiency. The plasma fatty acid profiles were similar in infants with or without topical oil, and all returned to normal once parenteral lipid was introduced. We found no evidence to suggest that the transdermal route is of use in the nutritional management of preterm infants.
对于未接受脂质补充的经肠道外喂养的早产儿，评估了局部涂抹植物油作为提供必需脂肪酸（EFA）的一种替代方法。研究了3对胎龄在26 - 32周的婴儿。每天将红花油或红花油酯（1克亚油酸/千克/天）涂抹于可涂抹部位。所有婴儿均迅速出现生化性必需脂肪酸缺乏。涂抹或未涂抹局部用油的婴儿血浆脂肪酸谱相似，且一旦引入肠道外脂质，所有婴儿的血浆脂肪酸谱均恢复正常。我们没有发现证据表明经皮途径可用于早产儿的营养管理。
