Flynn T G
Metabolism. 1986 Apr;35(4 Suppl 1):105-8. doi: 10.1016/0026-0495(86)90197-6.
The aldehyde reductases comprise a group of monomeric NADPH-dependent oxidoreductases with a broad and similar substrate specificity. Three major reductases, ALR1, ALR2, and ALR3, occur in tissues. The predominant one, ALR1, is aldehyde reductase; ALR2 is aldose reductase, an enzyme implicated in the etiology of diabetic complications; and ALR3 is carbonyl reductase, the only reductase with any affinity for ketones. ALR1 and ALR2 are immunologically nonrelated, and little immunologic relatedness exists between aldehyde reductases, particularly ALR1, from different species. The evolutionary relatedness of ALR2, however, may be closer, particularly among the primates. ALR2 from human and monkey tissues are immunologically identical.
醛还原酶是一组单体的、依赖NADPH的氧化还原酶，具有广泛且相似的底物特异性。组织中存在三种主要的还原酶，即ALR1、ALR2和ALR3。其中占主导地位的ALR1是醛还原酶；ALR2是醛糖还原酶，一种与糖尿病并发症病因有关的酶；而ALR3是羰基还原酶，是唯一对酮有亲和力的还原酶。ALR1和ALR2在免疫学上不相关，不同物种的醛还原酶之间，尤其是ALR1，几乎不存在免疫学相关性。然而，ALR2的进化相关性可能更近，尤其是在灵长类动物中。人和猴组织中的ALR2在免疫学上是相同的。
