Animal Pathology Department, Instituto Universitario de Investigaciones Biomédicas y Universitarias, Universidad de Las Palmas de Gran Canaria, 35416 Trasmontaña S/N, Arucas, Spain.
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain.
Int J Mol Sci. 2019 Mar 1;20(5):1075. doi: 10.3390/ijms20051075.
The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has not yet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bone fractures in dogs. With this objective, sixty-five dogs with radius/ulna or tibia/fibula bone fractures were randomly divided into two groups (PRGF and saline solution (SS) groups) and checked at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 60, 63, 70, 120, and 180. All the fractures were treated with an external skeletal fixation, and pain was controlled with Carprofen. Healing was evaluated by physical examination, limb function, radiography, and by a Likert-type owner satisfaction questionnaire. A faster fracture healing was observed in the PRGF group, with statistically significant differences with respect to the SS group. Swelling at the fracture site was significantly greater at day 14 and 28 in animals injected with PRGF, and more pain on palpation was found in the area at day 28. The injection of PRGF in acute bone fractures accelerates bone healing.
富血小板血浆（PRP）在促进骨折愈合中的作用尚未明确。本前瞻性临床研究旨在评估富含生长因子的血浆（PRGF，PRP 的衍生物）在治疗犬自然发生的骨折中的效果。为此，将 65 只桡骨/尺骨或胫骨/腓骨骨折的狗随机分为两组（PRGF 组和生理盐水（SS）组），在第 0、7、14、21、28、35、42、49、56、60、63、70、120 和 180 天进行检查。所有骨折均采用外固定架治疗，并使用卡洛芬控制疼痛。通过体格检查、肢体功能、X 射线和 Likert 型主人满意度问卷评估愈合情况。PRGF 组的骨折愈合更快，与 SS 组相比具有统计学意义。PRGF 注射后第 14 天和第 28 天骨折部位肿胀明显更大，第 28 天触诊时疼痛更明显。在急性骨骨折中注射 PRGF 可加速骨愈合。
