Hernández-Guerra Ángel María, Carrillo José María, Sopena Joaquín Jesús, Vilar José Manuel, Peláez Pau, Cuervo Belén, Santana Angelo, Rubio Mónica
Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain.
Department of Animal Pathology, Instituto Universitario de Investigaciones Biomédicas y Universitarias, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, 35416 Arucas, Spain.
Animals (Basel). 2021 Oct 14;11(10):2965. doi: 10.3390/ani11102965.
Traditionally, canine degenerative lumbosacral stenosis (DLS) has been defined as a multifactorial syndrome characterized by lumbosacral pain triggered by the compression of the nerve rootlets of the cauda equina. There is still no consensus on the treatment of this condition, probably because there are a plethora of possible causes. In addition to compression, inflammation is a very important factor in the physiopathology of the disorder. Platelet-rich plasma (PRP) consists of an increased concentration of autologous platelets suspended in a small amount of plasma. Platelets are a source of several growth factors. Growth factors were shown to help in wound healing and biological processes, such as chemotaxis, neovascularization and synthesis of extracellular matrix, and growth factors were used to improve soft tissue healing and bone regeneration. PRP also facilitates the restoration of the structural integrity of the affected anatomy. Fourteen dogs diagnosed with DLS were treated with three epidural injections of PRP on days 0, 15 and 45. All dogs showed clinical improvement 3 months after the initial treatment. Gait was also objectively assessed by means of the use of force platform analysis before and after treatment, showing significant improvement. The results show that PRP may provide a good alternative to other nonsurgical treatments, such as prednisolone epidural injection.
传统上，犬退行性腰椎管狭窄症（DLS）被定义为一种多因素综合征，其特征是马尾神经根受压引发腰骶部疼痛。对于这种病症的治疗仍未达成共识，可能是因为存在众多可能的病因。除了压迫之外，炎症在该病症的病理生理学中也是一个非常重要的因素。富血小板血浆（PRP）由悬浮在少量血浆中的自体血小板浓度增加组成。血小板是多种生长因子的来源。生长因子已被证明有助于伤口愈合和生物过程，如趋化作用、新血管形成和细胞外基质合成，并且生长因子被用于改善软组织愈合和骨再生。PRP还促进受影响解剖结构的结构完整性恢复。14只被诊断为DLS的犬在第0天、第15天和第45天接受了三次硬膜外注射PRP治疗。所有犬在初始治疗3个月后均显示出临床改善。治疗前后还通过使用测力平台分析对步态进行了客观评估，结果显示有显著改善。结果表明，PRP可能为其他非手术治疗方法，如泼尼松龙硬膜外注射，提供一个良好的替代方案。
