Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.
Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.
Viruses. 2019 Mar 2;11(3):211. doi: 10.3390/v11030211.
Koalas () are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship between abundance and ocular disease in koalas, suggesting that the co-infection of Burpengary virus and is inhibited.
考拉（）是澳大利亚本土有袋动物，其数量因多种威胁而减少。由细菌 和其他病原体引起的传染病尤其令人担忧。我们分析了一组旨在研究考拉对眼衣原体感染的免疫反应的数据集的 26 个 poly-A 选择 RNA-seq 文库。使用病毒发现技术，我们鉴定了一种新型微小 RNA 样病毒的编码完整基因组序列，命名为伯朋加里病毒，该病毒在昆士兰州东南部最为常见。值得注意的是，对所有 26 个文库的病毒丰度测量显示，病毒丰度与考拉眼部疾病呈负相关，表明伯朋加里病毒和 的合并感染受到抑制。
