Aeschbacher H U
Mutat Res. 1986 Apr;164(2):109-15. doi: 10.1016/0165-1161(86)90049-x.
It has previously been shown that the inbred mouse strain MS/Ae was more sensitive in the micronucleus test to several mutagenic agents than outbred mice. To elucidate the possible influence of inbreeding, several inbred strains including MS/Ae, AKR, BALB/c, C57 BR were compared to the two OF1 and NMRI outbred strains. The 3 mutagenic agents MNNG, MMC and MMS all induced a significantly higher number of micronuclei in the MS/Ae strain than in any of the other mouse strains. AKR was especially resistant to the alkylating agents MMS and MNNG. Hence, except for the MS/Ae mouse strain, no inbred strain showed a systematically higher sensitivity than the outbred strains for all of the 3 mutagenic agents used.
先前的研究表明，在微核试验中，近交系小鼠品系MS/Ae对几种诱变剂的敏感性高于远交系小鼠。为了阐明近亲繁殖可能产生的影响，将包括MS/Ae、AKR、BALB/c、C57 BR在内的几个近交系与两个远交系OF1和NMRI进行了比较。三种诱变剂MNNG、MMC和MMS在MS/Ae品系中诱导产生的微核数量均显著高于其他任何小鼠品系。AKR对烷基化剂MMS和MNNG具有特别的抗性。因此，除了MS/Ae小鼠品系外，对于所使用的所有三种诱变剂，没有一个近交系表现出比远交系更高的系统性敏感性。
