Sutou S, Sato S
Itoham Central Research Institute, Ibaraki, Japan.
Environ Mol Mutagen. 1990;15(3):125-30. doi: 10.1002/em.2850150302.
MS/Ae mice, which are mutagen-sensitive in both the dominant lethal test and micronucleus test, and CD-1 mice, which are the parental strain of MS/Ae, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6-mercaptopurine (6-MP). Col showed equivocal results. However, MMC and 6-MP showed differential responses in that both male and female offspring from CD-1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MS/Ae dams were lower than those from CD-1 dams regardless of sire strain. Numbers of offspring from MS/Ae dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.
在显性致死试验和微核试验中均对诱变敏感的MS/Ae小鼠，以及作为MS/Ae亲本品系的CD-1小鼠，以所有四种可能的组合进行交配。对雄性和雌性后代均使用丝裂霉素C（MMC）、秋水仙碱（Col）和6-巯基嘌呤（6-MP）进行微核试验。Col的结果不明确。然而，MMC和6-MP表现出不同的反应，即无论父本品系如何，来自CD-1母鼠的雄性和雌性后代的微核多染红细胞发生率均低于来自MS/Ae母鼠的后代。此外，无论父本品系如何，来自MS/Ae母鼠的后代体重均低于来自CD-1母鼠的后代。来自MS/Ae母鼠的后代数量往往少于来自CD母鼠的后代。这些结果表明，MS/Ae小鼠的性状与母本因素的关联大于与父本因素的关联。
