Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, PR China; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, 223002, Jiangsu, PR China.
Department of Emergency, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300, Jiangsu, PR China.
Carbohydr Polym. 2019 May 15;212:1-10. doi: 10.1016/j.carbpol.2019.02.026. Epub 2019 Feb 12.
As a fungal polysaccharide, polysaccharide (PPUS) from Polyporus umbellatus sclerotia have showed remarkable anti-inflammatory activities. In view of the closely relationship between inflammation and renal fibrosis, and considering the significant role of other fungal polysaccharides on treatment of renal fibrosis, we speculated that PPUS may have therapeutic effects on renal fibrosis. However, there was not any reports about PPUS treatment this disease. The purpose of this paper is to investigate renoprotective effect and mechanism of PPUS on renal fibrosis. The results indicated that PPUS can improve renal function and ameliorate the degree of renal collagen deposition and further fibrosis. Its mechanism was found to be related with decreased inflammation, suppressive epithelial-mesenchymal transition, reconstructed the balance of matrix metalloproteinases and tissue inhibitor of metalloproteinases, and pro-fibrotic and anti-fibrotic factors. The data implied that PPUS can serve as a clinical candidate on treatment of renal interstitial fibrosis.
作为一种真菌多糖，药用真菌猪苓多糖（PPUS）具有显著的抗炎活性。鉴于炎症与肾纤维化之间的密切关系，以及其他真菌多糖在治疗肾纤维化方面的重要作用，我们推测 PPUS 可能对肾纤维化具有治疗作用。然而，目前尚无关于 PPUS 治疗该疾病的报道。本文旨在探讨 PPUS 对肾纤维化的保护作用及其机制。结果表明，PPUS 可改善肾功能，减轻肾脏胶原沉积和进一步纤维化的程度。其作用机制与降低炎症、抑制上皮-间充质转化、重建基质金属蛋白酶和组织金属蛋白酶抑制剂的平衡以及促纤维化和抗纤维化因子有关。这些数据表明，PPUS 可以作为治疗肾间质纤维化的临床候选药物。
