Nishino H, Ono T, Takahashi J, Kimura M, Shiosaka S, Tohyama M
Neurosci Lett. 1986 Feb 28;64(2):184-90. doi: 10.1016/0304-3940(86)90097-2.
The correlation between the growth of transplanted cells and behavior recovery in rats with lesions in the unilateral nigrostriatal dopamine (DA) pathway was investigated. Grafted cells in the lateral or third ventricle grew better than those in the caudate parenchyma. Immunocytochemical staining of tyrosine hydroxylase (TH) revealed that axons or dendrites of TH-like immunoreactive (TH-LI) cells transplanted periventricularly extended and ramified better than those of cells implanted in the central parenchyma of the caudate nucleus. The extent of ramification was well correlated with the recovery of behavioral imbalance. Data suggest that the growth and ramification of transplanted TH-LI cells are the most critical factors affecting behavior recovery, and this growth depends on the transplantation sites.
研究了单侧黑质纹状体多巴胺（DA）通路损伤大鼠移植细胞生长与行为恢复之间的相关性。移植到侧脑室或第三脑室的细胞比移植到尾状实质的细胞生长得更好。酪氨酸羟化酶（TH）的免疫细胞化学染色显示，经脑室周围移植的TH样免疫反应性（TH-LI）细胞的轴突或树突比植入尾状核中央实质的细胞延伸和分支得更好。分支程度与行为失衡的恢复密切相关。数据表明，移植的TH-LI细胞的生长和分支是影响行为恢复的最关键因素，而这种生长取决于移植部位。
