Department of Psychiatry, Columbia University Medical Center, New York, NY, 10032, USA.
Division of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY, 10032, USA.
J Perinatol. 2019 May;39(5):608-618. doi: 10.1038/s41372-019-0342-9. Epub 2019 Mar 4.
To determine normative values for heart rate patterns in healthy fetuses.
This research is from the Safe Passage Study conducted by the Prenatal Alcohol and SIDS and Stillbirth (PASS) Network. A standardized protocol assessed fetal heart rate (FHR), heart rate variability (HRV), and movement from 1655 fetuses at three-time points during gestation (20-24 weeks, 28-32 weeks, 34-38 weeks gestation).
FHR decreased while HRV increased over gestation. At the latter two ages, males had significantly lower FHR than females while there were no sex differences in FHR at 20-24 weeks. When accounting for the fetal state during late gestation (34-28 weeks), we found that males had significantly lower FHR than females in the active fetal state only.
Results demonstrate significant state, gestational age, and sex-related changes in cardiac activity, somatic activity, and autonomic function as the fetus approaches birth.
确定健康胎儿心率模式的正常值。
这项研究来自产前酒精和 SIDS 及死胎（PASS）网络进行的安全通道研究。一项标准化方案评估了 1655 名胎儿在妊娠三个时间点（20-24 周、28-32 周、34-38 周）的胎儿心率（FHR）、心率变异性（HRV）和运动。
FHR 在妊娠期间逐渐下降，而 HRV 逐渐增加。在后两个年龄段，男性的 FHR 明显低于女性，而在 20-24 周时，FHR 没有性别差异。当考虑到晚期妊娠（34-28 周）的胎儿状态时，我们发现只有在胎儿活跃状态下，男性的 FHR 明显低于女性。
研究结果表明，随着胎儿接近出生，心脏活动、躯体活动和自主功能存在显著的状态、胎龄和性别相关变化。
