韩国特发性炎性肌病的发病率和患病率：一项全国范围内基于人群的研究。
Incidence and Prevalence of Idiopathic Inflammatory Myopathies in Korea: a Nationwide Population-based Study.
机构信息
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, Korea.
出版信息
J Korean Med Sci. 2019 Feb 8;34(8):e55. doi: 10.3346/jkms.2019.34.e55. eCollection 2019 Mar 4.
BACKGROUND
This study aimed to estimate the incidence and prevalence of idiopathic inflammatory myopathies (IIM) and associated comorbidities in Korea from 2006 to 2015.
METHODS
IIM between 2004 to 2015 were identified using the Korean National Health Insurance Service medical claim database. The case definition required more than one visit based on diagnostic codes including juvenile dermatomyositis (JDM), dermatomyositis (DM), or polymyositis (PM) and registration in the Individual Copayment Beneficiaries Program (ICBP) for rare and intractable diseases. IIM patients with a disease-free period of 24 months before the index date were defined as incident cases. The Elixhauser comorbidity score was calculated.
RESULTS
Using the base case definition, 1,150 prevalent patients with IIM (117 JDM, 521 DM, 512 PM) were recorded in 2006 and 2,210 (130 JDM, 1,101 DM, 869 PM) in 2015. The prevalence was estimated at 2.3-4.0 (0.9-1.2 for JDM, 1.2-2.7 for DM, 1.4-2.1 for PM)/100,000 person-year (PY). We identified 218 incident cases of IIM in 2006 (18 JDM, 98 DM, 102 PM) and 191 cases (7 JDM, 83 DM, 101 PM) in 2015. The incidence was estimated at 2.9-5.2 (0.7-1.9 for JDM, 1.8-4.0 for DM, 1.6-3.0 for PM)/1,000,000 PY. The mean age (± standard deviation) of prevalent patients with IIM was 51.2 (± 16.9) years, and the percentage of women was 72.1%. More than two-thirds of patients (70.7%) had more than two comorbidities. Twenty percent of patients had interstitial lung diseases.
CONCLUSION
In Korea, the incidence and prevalence of IIM were 2.9-5.2/1,000,000 PY and 2.3-4.0/100,000 PY, respectively.
背景
本研究旨在评估 2006 年至 2015 年期间韩国特发性炎性肌病（IIM）的发病率和患病率以及相关合并症。
方法
使用韩国国家健康保险服务医疗索赔数据库，从 2004 年至 2015 年确定 IIM 病例。病例定义要求根据包括幼年皮肌炎（JDM）、皮肌炎（DM）或多发性肌炎（PM）在内的诊断代码进行一次以上就诊，并在罕见和难治性疾病个人自费受益计划（ICBP）中登记。索引日期前无疾病间隔 24 个月的 IIM 患者被定义为新发病例。计算了 Elixhauser 合并症评分。
结果
使用基本病例定义，2006 年记录了 1150 例现患 IIM 患者（117 例 JDM、521 例 DM、512 例 PM），2015 年记录了 2210 例（130 例 JDM、1101 例 DM、869 例 PM）。患病率估计为 2.3-4.0（0.9-1.2 为 JDM、1.2-2.7 为 DM、1.4-2.1 为 PM）/100000 人年（PY）。2006 年确定了 218 例 IIM 新发病例（18 例 JDM、98 例 DM、102 例 PM），2015 年确定了 191 例（7 例 JDM、83 例 DM、101 例 PM）。发病率估计为 2.9-5.2（0.7-1.9 为 JDM、1.8-4.0 为 DM、1.6-3.0 为 PM）/1000000 PY。现患 IIM 患者的平均年龄（±标准差）为 51.2（±16.9）岁，女性占 72.1%。超过三分之二的患者（70.7%）有两种以上合并症。20%的患者患有间质性肺病。
结论
在韩国，IIM 的发病率和患病率分别为 2.9-5.2/1000000PY 和 2.3-4.0/100000PY。
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