Kara Elodie, Dupuy Laurence, Bouillon Céline, Casteret Sophie, Maurel Marie-Christine
Igyxos SA, Nouzilly, France.
Service de Médecine et Biologie de la Reproduction, CHRU de Tours, Tours, France.
Front Endocrinol (Lausanne). 2019 Feb 18;10:15. doi: 10.3389/fendo.2019.00015. eCollection 2019.
Gonadotropins are essential for reproduction control in humans as well as in animals. They are widely used all over the world for ovarian stimulation in women, spermatogenesis stimulation in men, and ovulation induction and superovulation in animals. Despite the availability of many different preparations, all are made of the native hormones. Having different ligands with a wide activity range for a given receptor helps better understand its molecular and cellular signaling mechanisms as well as its physiological functions, and thus helps the development of more specific and adapted medicines. One way to control the gonadotropins' activity could be the use of modulating antibodies. Antibodies are powerful tools that were largely used to decipher gonadotropins' actions and they have shown their utility as therapeutics in several other indications such as cancer. In this review, we summarize the inhibitory and potentiating antibodies to gonadotropins, and their potential therapeutic applications.
促性腺激素对于人类和动物的生殖控制至关重要。它们在全世界被广泛用于刺激女性卵巢、刺激男性精子发生以及诱导动物排卵和超排卵。尽管有许多不同的制剂，但所有制剂均由天然激素制成。拥有针对给定受体具有广泛活性范围的不同配体有助于更好地理解其分子和细胞信号传导机制以及其生理功能，从而有助于开发更具特异性和适应性的药物。控制促性腺激素活性的一种方法可能是使用调节性抗体。抗体是强大的工具，在很大程度上被用于解读促性腺激素的作用，并且它们已在包括癌症在内的其他几种适应症中显示出作为治疗剂的效用。在本综述中，我们总结了针对促性腺激素的抑制性和增强性抗体及其潜在的治疗应用。
