Zeng Jianfeng, Wang Shanyun, Zhong Liang, Huang Zhifeng, Zeng Ye, Zheng Dongxiang, Zou Weiwei, Lai Haibiao
Department of Urology Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated With Guangzhou University of Chinese Medicine, Zhongshan City, China.
Department of Obstetrics and Gynecology, Zhongshan Hospital of Traditional Chinese Medicine Affiliated With Guangzhou University of Chinese Medicine, Zhongshan City, China.
J Clin Med Res. 2019 Mar;11(3):208-212. doi: 10.14740/jocmr3753. Epub 2019 Feb 13.
Nephrolithiasis or kidney stone disease (KSD) is a common disorder worldwide. Despite the availability of a variety of effective management strategies, KSD recurrence remains a problem. In the present study, we investigated the KSD recurrence after the treatment of the first stone episode.
Medical records of all patients who had KDS treated in our department from January 2012 to January 2016 were retrospectively reviewed. A total of 146 patients who had KDS recurrence were identified. The demographic information, biochemical data, treatment methods, report of hydronephrosis severity and stone chemical compositions were collected and analyzed.
We reported that: 1) Sixty four (43.8%) out of 146 patients with stone recurrence were overweight or obese; 2) Of all 146 patients with stone recurrence, 86 (58.9%) had hyperlipidemia, 77 (52.4%) had hyperuricemia and 64 (43.8%) had hyperglycemia; 3) Mini-invasive methods were mostly used for the treatment of the first stone episode; 4) The most chief complaint differed during the first episode and recurrence; 5) The number of patients who had grades 3 and 4 hydronephrosis was significantly lower during recurrence compared with that in the first stone episode; 6) Seventy nine (54.1%) patients with recurrence had stone of calcium oxalate.
Majority of patients with KSD recurrence have overweight/obesity, hyperlipidemia, hyperuricemia and hyperglycemia, indicating a role of metabolic disorders in stone recurrence. Mini-invasive methods are the mainstay for the management of the first stone episode. The degree of hydronephrosis is significantly reduced during stone recurrence, possibly due to increased awareness of the disease and thereafter the change of lifestyle in patients. Over half of recurrent stones are of calcium oxalate.
肾结石病在全球范围内是一种常见疾病。尽管有多种有效的治疗策略，但肾结石病的复发仍然是一个问题。在本研究中，我们调查了首次结石发作治疗后的肾结石病复发情况。
回顾性分析了2012年1月至2016年1月在我科接受治疗的所有肾结石病患者的病历。共确定了146例肾结石病复发患者。收集并分析了人口统计学信息、生化数据、治疗方法、肾盂积水严重程度报告和结石化学成分。
我们报告如下：1）146例结石复发患者中有64例（43.8%）超重或肥胖；2）在所有146例结石复发患者中，86例（58.9%）患有高脂血症，77例（52.4%）患有高尿酸血症，64例（43.8%）患有高血糖；3）首次结石发作的治疗大多采用微创方法；4）首次发作和复发时的主要症状不同；5）复发时3级和4级肾盂积水患者的数量明显低于首次结石发作时；6）79例（54.1%）复发患者的结石为草酸钙结石。
大多数肾结石病复发患者存在超重/肥胖、高脂血症、高尿酸血症和高血糖，表明代谢紊乱在结石复发中起作用。微创方法是首次结石发作治疗的主要手段。结石复发时肾盂积水程度明显减轻，可能是由于患者对疾病的认识提高以及生活方式的改变。超过一半的复发性结石为草酸钙结石。
