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超声冲击波碎石术的多物理场分析及其对周围组织的副作用

Multiphysics Analysis of Ultrasonic Shock Wave Lithotripsy and Side Effects on Surrounding Tissues.

作者信息

Moghimnezhad Mahdi, Shahidian Azadeh, Andayesh Mohammad

机构信息

MSc, Department of Mechanical Engineering, K. N . Toosi University of Technology, Tehran, Iran.

PhD, Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.

出版信息

J Biomed Phys Eng. 2021 Dec 1;11(6):701-712. doi: 10.31661/jbpe.v0i0.1182. eCollection 2021 Dec.

DOI:10.31661/jbpe.v0i0.1182
PMID:34904067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8649164/
Abstract

BACKGROUND

Today, the most common method for kidney stone therapy is extracorporeal shock wave lithotripsy. Current research is a numerical simulation of kidney stone fragmentation via ultrasonic shock waves. Most numerical studies in lithotripsy have been carried out using the elasticity or energy method and neglected the dissipation phenomenon. In the current study, it is solved by not only the linear acoustics equation, but also the Westervelt acoustics equation which nonlinearity and dissipation are involved.

OBJECTIVE

This study is to compare two methods for simulation of shock wave lithotripsy, clarifying the effect of shock wave profiles and stones' material, and investigating side effects on surrounding tissues.

MATERIAL AND METHODS

Computational study is done using COMSOL Multiphysics, commercial software based on the finite element method. Nonlinear governing equations of acoustics, elasticity and bioheat-transfer are coupled and solved.

RESULTS

A decrease in the rise time of shock wave leads to increase the produced acoustic pressure and enlarge focus region. The shock wave damages kidney tissues in both linear and nonlinear simulation but the damage due to high temperature is very negligible compared to the High Intensity Focused Ultrasound (HIFU).

CONCLUSION

Disaffiliation of wave nonlinearity causes a high incompatibility with reality. Stone's material is an important factor, affecting the fragmentation.

摘要

背景

如今，肾结石治疗最常用的方法是体外冲击波碎石术。当前的研究是对通过超声波冲击波进行肾结石破碎的数值模拟。碎石术中的大多数数值研究都是使用弹性或能量方法进行的，并且忽略了耗散现象。在当前的研究中，不仅通过线性声学方程，而且通过涉及非线性和耗散的韦斯特维尔特声学方程来解决该问题。

目的

本研究旨在比较两种模拟冲击波碎石术的方法，阐明冲击波波形和结石材料的影响，并研究对周围组织的副作用。

材料与方法

使用基于有限元方法的商业软件COMSOL Multiphysics进行计算研究。耦合并求解声学、弹性和生物传热的非线性控制方程。

结果

冲击波上升时间的减少会导致产生的声压增加并扩大聚焦区域。在线性和非线性模拟中，冲击波都会损伤肾脏组织，但与高强度聚焦超声（HIFU）相比，高温造成的损伤非常小。

结论

波的非线性缺失导致与实际情况高度不相符。结石材料是影响破碎的一个重要因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce83/8649164/b6fffa4b1657/JBPE-11-701-g011.jpg
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Full Modeling of High-Intensity Focused Ultrasound and Thermal Heating in the Kidney Using Realistic Patient Models.采用真实患者模型对高强度聚焦超声及肾脏热疗进行全面建模。
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