Elmakki Erwa Eltayib
Assistant professor Jazan University-Faculty of Medicine Internal Medicine/Gastroenterology, Jazan, 104 Saudi, Arabia.
Oman Med J. 2014 Jan;29(1):e065. doi: 10.5001/omj.2014.19.
Hepatocellular carcinoma is the most frequent type of liver malignancy. Most cases of hepatocellular carcinoma are secondary to either viral hepatitis (hepatitis B, C) or alcoholic cirrhosis. Liver cirrhosis due to any other causes is considered as a risk factor for development of hepatocellular carcinoma; however, hepatocellular carcinoma in a young patient with no cirrhosis or fibrosis is a relatively rare condition. The present case report describes a young 24-years-old male patient who presented with a two-month history of fever, right upper quadrant abdominal pain, and weight loss with no evidence of pre-existing liver disease, initially treated as liver abscess; however, a computed tomography (CT) showed numerous hepatic hypodensities with ring enhancement. Serum alpha-fetoprotein level was high (>1000 ng/L) and histopathological study confirmed the presence of primary hepatocellular carcinoma. The present case findings suggest that multifocal hepatocellular carcinoma can occur in a young patient with no apparent risk factor, and that the clinical presentation of hepatocellular carcinoma can be similar to liver abscess.
肝细胞癌是最常见的肝脏恶性肿瘤类型。大多数肝细胞癌病例继发于病毒性肝炎(乙型、丙型肝炎)或酒精性肝硬化。任何其他原因导致的肝硬化都被视为肝细胞癌发生的危险因素;然而,在没有肝硬化或纤维化的年轻患者中发生肝细胞癌是一种相对罕见的情况。本病例报告描述了一名24岁的年轻男性患者,他有两个月的发热、右上腹腹痛和体重减轻病史,且无既往肝病证据,最初被当作肝脓肿治疗;然而,计算机断层扫描(CT)显示肝脏有多处低密度影并伴有环形强化。血清甲胎蛋白水平很高(>1000 ng/L),组织病理学研究证实存在原发性肝细胞癌。本病例的发现表明,多灶性肝细胞癌可发生在没有明显危险因素的年轻患者中,且肝细胞癌的临床表现可能与肝脓肿相似。