Su Yu-Jang, Yang Hsiu-Wu
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Department of Oral Hygiene College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
J Drug Assess. 2019 Feb 6;8(1):21-24. doi: 10.1080/21556660.2019.1579727. eCollection 2019.
Purple urine bag syndrome (PUBS) is rarely seen in clinical practice. Several studies have reported that PUBS is relatively benign in its clinical course, but this study aimed to identify risk factors for mortality related to PUBS. In a PubMed search from October 1980 to August 2016, using the search term "Purple urine bag syndrome (PUBS)", 106 articles (n = 174 cases) were identified. This study excluded 58 cases. Among them, 14 cases did not include information on patient sex and four cases did not include information on patient age. Thirty-seven cases did not report the white blood cell (WBC) count, shock, fever, or etiology. Three cases did not report patient survival. This study considered 116 PUBS cases. Chi-square tests were used to compare the survival and mortality groups. In relative risk analysis, uremia (17.8), shock (14.4), diabetes (4.8), leukocytosis (1.1), and female sex (1.1) were significant risk factors for mortality after PUBS. However, it is possible that PUBS cases are under-reported worldwide. PUBS is a warning sign of a urinary tract infection, and it often follows a relatively benign clinical course. This study found that female sex, leukocytosis, shock at presentation, comorbidity with diabetes, and uremia are risk factors for mortality associated with PUBS.
紫色尿袋综合征（PUBS）在临床实践中很少见。几项研究报告称，PUBS的临床病程相对良性，但本研究旨在确定与PUBS相关的死亡风险因素。在1980年10月至2016年8月的PubMed搜索中，使用搜索词“紫色尿袋综合征（PUBS）”，共识别出106篇文章（n = 174例）。本研究排除了58例。其中，14例未包含患者性别信息，4例未包含患者年龄信息。37例未报告白细胞（WBC）计数、休克、发热或病因。3例未报告患者生存情况。本研究纳入了116例PUBS病例。采用卡方检验比较生存组和死亡组。在相对风险分析中，尿毒症（17.8）、休克（14.4）、糖尿病（4.8）、白细胞增多（1.1）和女性（1.1）是PUBS后死亡的显著风险因素。然而，全球范围内PUBS病例可能存在报告不足的情况。PUBS是尿路感染的一个警示信号，其临床病程通常相对良性。本研究发现，女性、白细胞增多、就诊时休克、合并糖尿病和尿毒症是与PUBS相关的死亡风险因素。
