Department of Obstetrics and Gynecology, School of Medicine, University of Salerno, Salerno, Italy.
Department of Maternal and Child Health and Urology, Sapienza University of Rome, Italy.
Biomed Res Int. 2019 Jan 31;2019:3726957. doi: 10.1155/2019/3726957. eCollection 2019.
To evaluate the impact on metabolism, bleeding, and sexual function of Nexplanon, a subdermal implant.
We recruited women (=101) receiving the Nexplanon implant at two university centers in Italy between 2011 and 2016 into this prospective, observational, multicenter research trial. Participants completed the Interview for Ratings of Sexual Function (IRSF) and the Female Sexual Function Index (FSFI) questionnaires before and 3 and 6 months after the implant was inserted. In addition, all blood parameters were assessed at these visits. All women were given a menstrual diary card and a pictorial blood assessment chart to record daily any vaginal bleeding.
The studied metabolic parameters remained in the normal range, showing no alarming modifications: minimal statistical reductions (in aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglycerides, and activated partial thromboplastin time) and increases (in glucose and prothrombin activity) were observed. Changes in IRSF score over 6 months showed a significant increase in pleasure, personal initiative, orgasm, intensity of orgasm, and satisfaction, and a significant decrease in anxiety and discomfort. Mean Body Mass Index decreased, and the weekly frequency of sexual intercourse increased.
Nexplanon showed not only a lower metabolic and bleeding impact, but also important positive effects on sexual function. It expands the range of possibilities for women, 38 and couples, in the modern concepts of sexual and reproductive wellbeing.
评估皮下埋植型避孕系统 Nexplanon 对代谢、出血和性功能的影响。
我们在意大利的两个大学中心招募了 2011 年至 2016 年间接受 Nexplanon 植入的女性（=101 名），开展这项前瞻性、观察性、多中心研究。参与者在植入前、植入后 3 个月和 6 个月时完成了性功能评估访谈（IRSF）和女性性功能指数（FSFI）问卷。此外，还在这些就诊时评估了所有血液参数。所有女性都收到了月经日记卡和图像出血评估图表，以记录每天的任何阴道出血情况。
研究中的代谢参数保持在正常范围内，没有出现令人担忧的变化：观察到最小的统计学减少（天冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆固醇、甘油三酯和活化部分凝血活酶时间）和增加（血糖和凝血酶原活性）。6 个月时 IRSF 评分的变化显示，愉悦感、个人主动性、性高潮、性高潮强度和满意度显著增加，焦虑和不适显著减少。平均体重指数下降，每周性生活频率增加。
Nexplanon 不仅对代谢和出血影响较小，而且对性功能有重要的积极影响。它扩展了女性和夫妻在现代性和生殖健康概念中的可能性范围。
