Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC G1V 0A6, Canada.
Org Biomol Chem. 2019 Mar 20;17(12):3098-3102. doi: 10.1039/c9ob00261h.
Fe(OTf)2 was used to catalyze the insertion reaction of α-diazocarbonyls into S-H bonds at 40 °C. A wide range of α-thioesters were obtained in yields up to 96% within 24-48 h from their corresponding α-diazoesters. A variety of thiols were used for the unprecedented insertion reaction with an α-diazoketone, leading to yields up to 85% of α-thioketones.
Fe(OTf)2 用于催化 α-二羰基化合物在 40°C 下插入 S-H 键。在 24-48 小时内，从相应的 α-重氮酯可得到产率高达 96%的α-硫代酯。各种硫醇用于前所未有的α-二氮酮的插入反应，得到产率高达 85%的α-硫代酮。
