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Determination of vancomycin exposure target and individualised dosing recommendations for neonates: model-informed precision dosing.万古霉素暴露目标的确定和新生儿个体化给药建议：模型指导下的精准给药。
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Ann Pharmacother. 2011 May;45(5):687-9. doi: 10.1345/aph.1P495. Epub 2011 Apr 26.

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Factors affecting free vancomycin concentration and target attainment of free area under the concentration-time curve.影响游离万古霉素浓度及浓度-时间曲线下游离面积目标达成的因素。
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Population Pharmacokinetics of Vancomycin in Pregnant Women.万古霉素在孕妇中的群体药代动力学。
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Variation in vancomycin dosing and therapeutic drug monitoring practices in neonatal intensive care units.新生儿重症监护病房万古霉素给药剂量及治疗药物监测实践的差异。
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Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine.晚期早产儿和足月儿细菌感染的分层管理：精准医学的当前策略与未来机遇
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本文引用的文献

1
Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.个体数据的群体药代动力学荟萃分析，旨在设计万古霉素在新生儿和婴幼儿中的首次随机疗效试验。
J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138. doi: 10.1093/jac/dkz158.
2
Factors impacting unbound vancomycin concentrations in neonates and young infants.影响新生儿和婴儿游离万古霉素浓度的因素。
Eur J Clin Microbiol Infect Dis. 2018 Aug;37(8):1503-1510. doi: 10.1007/s10096-018-3277-8. Epub 2018 May 16.
3
Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?新生儿凝固酶阴性葡萄球菌败血症：我们是否需要调整万古霉素剂量或治疗目标？
BMC Pediatr. 2016 Dec 8;16(1):206. doi: 10.1186/s12887-016-0753-0.
4
Unanswered Questions Regarding Optimal Pediatric Vancomycin Use.
Ther Drug Monit. 2016 Jun;38(3):419-20. doi: 10.1097/FTD.0000000000000289.
5
Duration of vancomycin treatment for coagulase-negative Staphylococcus sepsis in very low birth weight infants.万古霉素治疗极低出生体重儿凝固酶阴性葡萄球菌败血症的疗程。
Br J Clin Pharmacol. 2013 Jul;76(1):58-64. doi: 10.1111/bcp.12053.
6
External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings.新生儿万古霉素群体药代动力学模型的外部评估：已发表模型在不同临床环境中的可转移性。
Br J Clin Pharmacol. 2013 Apr;75(4):1068-80. doi: 10.1111/j.1365-2125.2012.04406.x.
7
Use of antibacterial agents in the neonate: 50 years of experience with vancomycin administration.新生儿抗菌药物的使用：万古霉素给药 50 年的经验。
Semin Fetal Neonatal Med. 2013 Feb;18(1):28-34. doi: 10.1016/j.siny.2012.10.003. Epub 2012 Nov 6.
8
Renal drug clearance in preterm neonates: relation to prenatal growth.早产儿的肾脏药物清除率：与产前生长的关系。
Ther Drug Monit. 2007 Jun;29(3):284-91. doi: 10.1097/FTD.0b013e31806db3f5.
9
Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections.万古霉素及其他抗菌药物在金黄色葡萄球菌下呼吸道感染患者中的药效学
Clin Pharmacokinet. 2004;43(13):925-42. doi: 10.2165/00003088-200443130-00005.

Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates.

作者信息

Leroux Stéphanie, van den Anker Johannes N, Smits Anne, Pfister Marc, Allegaert Karel

机构信息

Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

Neonatal Intensive Care Unit, University Hospital Rennes, Rennes, France.

出版信息

Br J Clin Pharmacol. 2019 May;85(5):865-867. doi: 10.1111/bcp.13899. Epub 2019 Mar 4.

DOI:10.1111/bcp.13899
PMID:30834552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6475736/
Abstract
摘要