Department of Dermatology and Allergology, University Hospital of Munich LMU, Munich, Germany.
J Eur Acad Dermatol Venereol. 2019 Jul;33(7):1304-1311. doi: 10.1111/jdv.15547. Epub 2019 Apr 10.
High-risk α-genus human papillomaviruses (α-HPVs) are linked to cervical and genital carcinomas; however, their correlation with cutaneous squamous cell carcinoma (cuSCC) or premalignant skin lesions remains controversial.
We evaluated the contribution of high-risk α-HPV to the occurrence of cuSCC, Bowen's disease and actinic keratosis (AK), and the distribution of high-risk α-HPV genotypes in these cutaneous tumours.
HPV genotypes were determined using a commercial PCR-based microarray on skin tissue samples collected from 76 [38 young (<60 years) and 38 elderly (>60 years)] cuSCC, 34 Bowen's disease, 48 AK patients and 10 young controls. Associations between α-HPV prevalence and relevant risk factors were analysed.
High-risk α-HPV was more frequently detected in cuSCC patients (57.9%) than in the patients with Bowen's disease (38.2%), AK (0.0%) and control patients (10.0%). The high-risk α-HPV prevalence was higher in young than in elderly cuSCC patients (65.8% vs. 50.0%, P = 0.031). The most common HPV type was 16, present in 90.9% of all HPV-carrying cuSCC patients. Multiple infections with different high-risk α-HPV types were found in 20.5% of HPV-related cuSCC, whereas only single infection with type 16 was found in Bowen's disease. Although sun exposure is known as a major risk factor for cuSCC, high-risk α-HPVs were more frequently found in non-exposed sites rather than in sun-exposed sites of cuSCC.
Multiple infections, as well as single infection with high-risk α-HPV may link to cuSCC. In spite of the involvement of high-risk α-HPV at high levels in cuSCC and Bowen's disease, no high-risk α-HPV was detected in AK patients, suggesting that Bowen's disease rather than AK might be involved in the development of HPV-related cuSCC as a precursor.
高危α 属人乳头瘤病毒（α-HPV）与宫颈癌和生殖器癌有关；然而，其与皮肤鳞状细胞癌（cuSCC）或癌前皮肤病变的相关性仍存在争议。
我们评估高危 α-HPV 对 cuSCC、鲍文病和光化性角化病（AK）发生的影响，并分析高危 α-HPV 基因型在这些皮肤肿瘤中的分布。
使用商业基于 PCR 的微阵列检测 76 例皮肤组织样本（38 例年轻患者(<60 岁)和 38 例老年患者(>60 岁)）、34 例鲍文病、48 例 AK 患者和 10 例年轻对照者中的 HPV 基因型。分析 α-HPV 流行率与相关危险因素之间的关系。
高危 α-HPV 在 cuSCC 患者（57.9%）中的检出率高于鲍文病（38.2%）、AK（0.0%）和对照组（10.0%）患者。年轻 cuSCC 患者中高危 α-HPV 的流行率高于老年患者（65.8%比 50.0%，P=0.031）。所有 HPV 阳性 cuSCC 患者中最常见的 HPV 类型是 16，占 90.9%。HPV 相关 cuSCC 中有 20.5%存在不同高危 α-HPV 型别的多重感染，而鲍文病中仅发现单一 16 型感染。虽然阳光暴露是 cuSCC 的主要危险因素之一，但高危 α-HPV 更多地出现在 cuSCC 的非暴露部位而不是暴露部位。
多重感染以及高危 α-HPV 的单一感染可能与 cuSCC 相关。尽管高危 α-HPV 在 cuSCC 和鲍文病中高水平参与，但 AK 患者未检测到高危 α-HPV，这表明鲍文病而不是 AK 可能作为 HPV 相关 cuSCC 的前驱病变参与其发生。
