Limberis Catherine Lynne, Nayler Simon, Rapoport Bernardo Leon
Department of Internal Medicine, Bedford Gardens Hospital, Johannesburg, South Africa.
Drs Gritzman and Thatcher Inc. Laboratories, Randburg, Johannesburg, South Africa.
Case Rep Oncol. 2020 Dec 10;13(3):1474-1482. doi: 10.1159/000511460. eCollection 2020 Sep-Dec.
Cutaneous squamous cell carcinoma has presented an increasing burden globally, with the occurrence of metastatic cutaneous squamous cell carcinoma being a relatively rare event but presenting with significant challenges in management, and a paucity of treatment options. Waldenström's macroglobulinemia is similarly an infrequent diagnosis. We present a rare case of a synchronous diagnosis of cutaneous squamous cell carcinoma and Waldenström's macroglobulinemia with an associated lung mass with squamous differentiation. The considered origin of the lung mass was either metastatic cutaneous squamous cell carcinoma or a primary squamous cell carcinoma of the lung, representing a third primary malignancy. The report highlights complexities in diagnosis and management, particularly in a patient with multiple synchronous malignancies. It further emphasizes the need for expanded global availability of specific therapies, including PD-1 inhibitors.
皮肤鳞状细胞癌在全球范围内造成的负担日益加重，转移性皮肤鳞状细胞癌的发生相对罕见，但在治疗上面临重大挑战，且治疗选择匮乏。华氏巨球蛋白血症同样是一种罕见的诊断。我们报告了一例罕见病例，同时诊断出皮肤鳞状细胞癌和华氏巨球蛋白血症，并伴有一个具有鳞状分化的肺部肿块。肺部肿块的可能来源要么是转移性皮肤鳞状细胞癌，要么是原发性肺鳞状细胞癌，代表第三种原发性恶性肿瘤。该报告强调了诊断和治疗的复杂性，尤其是在患有多种同步恶性肿瘤的患者中。它进一步强调了扩大全球范围内特定疗法（包括PD-1抑制剂）可及性的必要性。
