发育成熟：果蝇 AstA 信号提供“亲吻”以促进生长。

Developmental Maturation: Drosophila AstA Signaling Provides a Kiss to Grow Up.

机构信息

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Curr Biol. 2019 Mar 4;29(5):R161-R164. doi: 10.1016/j.cub.2019.01.040.

DOI:10.1016/j.cub.2019.01.040

Abstract

Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conservation of molecular components has not been documented. A new study demonstrates that the insect neuropeptide allatostatin A and its receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar to the way in which their mammalian orthologs Kisspeptin and KISS1R induce puberty.

摘要

昆虫变态和哺乳动物青春期表现出相似的设计原则，但分子成分的保守性尚未得到证实。一项新的研究表明，昆虫神经肽 allatostatin A 及其受体 AstAR1 激活了启动变态的神经内分泌信号级联反应，类似于其哺乳动物同源物 Kisspeptin 和 KISS1R 诱导青春期的方式。