Department of Psychology, University of Liège, Belgium.
Department of Psychology, University of Liège, Belgium.
Behav Brain Res. 2019 Jun 3;365:110-113. doi: 10.1016/j.bbr.2019.03.002. Epub 2019 Mar 2.
Wheel-running in rodents can mitigate addiction-related effects of drugs of abuse like cocaine. However, conditioned place preference (CPP) experiments have reported conflicting results, a situation warranting further studies. Our purpose was to test whether wheel-running exercise during adolescence could impact the formation and long-term retention of CPP to cocaine in mice. Male C57BL/6 J mice were individually housed either with (n = 32) or without (n = 32) a running wheel from the age of 35 days. Behavioral testing began 3 weeks after such housing, mice underwent a baseline session followed by 10 once-daily conditioning sessions receiving peritoneal injections of 10 mg/kg cocaine and saline on alternate days (n = 16), control mice receiving saline every day (n = 16). One and 21 days after the last conditioning session, they were tested for CPP. Both groups exhibited comparable well-marked cocaine-induced CPP in both post-conditioning tests resulting in a negligible interaction between housing and the pharmacological treatment (η²p < 0.01). These results, along with the discrepancy found in the literature, question the nature (and the robustness) of the effects that exercise induces on CPP to cocaine.
在啮齿类动物中，转轮运动可以减轻可卡因等滥用药物引起的成瘾效应。然而，条件性位置偏好（CPP）实验报告了相互矛盾的结果，这需要进一步研究。我们的目的是测试青少年时期的转轮运动是否会影响可卡因 CPP 的形成和长期保持。雄性 C57BL/6J 小鼠从 35 天大开始分别单独饲养在带有（n=32）或不带有（n=32）转轮的笼子中。行为测试在这种饲养 3 周后开始，小鼠进行基线测试，然后进行 10 次每日一次的条件化测试，每隔一天接受 10mg/kg 可卡因和生理盐水的腹腔注射（n=16），对照组每天接受生理盐水（n=16）。在最后一次条件化测试后的 1 天和 21 天，对它们进行 CPP 测试。两组在两个后测试中都表现出类似的明显可卡因诱导的 CPP，导致饲养和药理学处理之间的相互作用可以忽略不计（η²p<0.01）。这些结果以及文献中的差异，质疑了运动对可卡因 CPP 诱导的性质（和稳健性）。
