Department of Dermatology, Xi Jing Hospital, the Fourth Military Medical University, Xi'an, 710032, PR China.
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, 29209, USA.
Photodiagnosis Photodyn Ther. 2019 Jun;26:97-100. doi: 10.1016/j.pdpdt.2019.03.002. Epub 2019 Mar 2.
Photodynamic therapy (PDT) is one of the treatment options for generalized facial flat warts, which results in elimination of virus and inhibition of proliferation of warts due to photochemical and phototoxic reactions. In this research, we attempted to evaluate the efficacy and safety profiles of a combination of 2940-nm laser and PDT for the treatment of generalized recalcitrant facial flat warts.
Retrospective analysis of the patients with recalcitrant facial warts was performed. Patients in the combined group (n = 40) were treated with a 2940-nm single spot abrasion followed by a PDT; while the PDT group (n = 40) received a PDT treatment only. The efficacy was assessed by the lesion numbers and lesion clearance rate. The effective rate was calculated with the cured and excellent response rates.
The combined group showed significant improvements in the total effective rate (77.5%vs. 57.5%, p = 0.0416) and average clearance rate (81.68±2.83% vs. 68.13 ± 3.97%, p = 0.0068) as compared with the PDT-only group. The degree of lesion clearance was positively correlated with the treatment times in both groups. After three months of follow-up, no relapse occurred in patients from either group. Furthermore, an accumulation of photosensitizer in the lesional areas was observed in the combined treatment group.
A combination of 2940-nm laser and PDT was safe and showed significantly more effect than PDT alone in treatment for recalcitrant facial flat warts, partially due to the improved uptake of photosensitizer after 2940-nm laser induced skin abrasion.
光动力疗法（PDT）是治疗泛发性扁平疣的一种治疗方法，它通过光化学反应和光毒性反应，既能消除病毒，又能抑制疣的增殖。在这项研究中，我们尝试评估 2940nm 激光联合 PDT 治疗泛发性顽固性扁平疣的疗效和安全性。
对难治性面部扁平疣患者进行回顾性分析。联合组（n=40）采用 2940nm 单点磨蚀后行 PDT 治疗；而 PDT 组（n=40）仅接受 PDT 治疗。通过皮损数量和皮损清除率评估疗效。有效率以痊愈率和优良率计算。
联合组总有效率（77.5%vs. 57.5%，p=0.0416）和平均清除率（81.68±2.83%vs. 68.13±3.97%，p=0.0068）均明显优于 PDT 组。两组皮损清除程度与治疗次数呈正相关。随访 3 个月，两组均无复发。此外，联合治疗组皮损处光敏剂蓄积。
2940nm 激光联合 PDT 治疗难治性扁平疣安全有效，疗效明显优于单纯 PDT，部分原因是 2940nm 激光诱导皮肤擦伤后光敏剂的摄取增加。
