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青少年面部泛发性寻常疣采用刮除术和光动力疗法联合治疗成功:一例报告

Successful Treatment of Generalized Facial Verrucae Vulgaris with a Combination of Curettage and Photodynamic Therapy in an Adolescent: A Case Report.

作者信息

Zhang Na, Chen Xinru, Ye Tianhui, Ge Hongping, Zhai Xiaoli, Wu Jun, Zhang Min, Wang Meiyan

机构信息

Department of Dermatology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.

Department of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2024 Jul 22;17:1695-1699. doi: 10.2147/CCID.S470435. eCollection 2024.

Abstract

Verrucae vulgaris are highly contagious keratotic lesions occurring on the skin caused by human papillomavirus. Generally, verrucae vulgaris are harmless to the body, but when they occur in specific areas such as the face or soles of the feet, they can profoundly impact an individual's quality of life and necessitate therapeutic intervention. Although several pharmacological and physical topical treatments are available, the results are often unsatisfactory in terms of efficacy and cosmetic outcome. Verrucae which typically occur widely on the face are usually Verrucae Planae. When Verrucae vulgaris does occur, it usually presents as single or occasional multiple lesions, rather than covering almost the entire face. In immunocompromised situations, verruca vulgaris can exhibit rare proliferative behavior. In this report, we present a 17-year-old male adolescent who was successfully treated for generalized facial verrucae vulgaris by using a combination of curettage and photodynamic therapy (PDT). The patient's prolonged use of topical corticosteroids and tacrolimus ointment on the face for eczema over several years is believed to have led to a localized immunosuppressive state of the facial skin, which is considered a significant factor in the outbreak of verrucae vulgaris. Additionally, the patient has a history of acne and frequently scratched face. The appearance of the Koebner phenomenon following scratching is considered another potential reason. This treatment achieved complete resolution and improved the patient's pre-existing acne problem, resulting in a satisfactory cosmetic outcome without any notable adverse effects or recurrence during the follow-up period. This highlighted that pre-treatment with curettage before PDT enhanced the efficiency of verrucae vulgaris treatment and reduced the cost.

摘要

寻常疣是由人乳头瘤病毒引起的发生在皮肤上的高度传染性角化性病变。一般来说,寻常疣对身体无害,但当它们出现在面部或脚底等特定部位时,会对个人生活质量产生深远影响,需要进行治疗干预。尽管有几种药物和物理局部治疗方法,但在疗效和美容效果方面结果往往不尽人意。通常广泛出现在面部的疣通常是扁平疣。当出现寻常疣时,通常表现为单个或偶尔多个病变,而不是几乎覆盖整个面部。在免疫功能低下的情况下,寻常疣可表现出罕见的增殖行为。在本报告中,我们介绍了一名17岁男性青少年,他通过刮除术和光动力疗法(PDT)联合治疗成功治愈了面部广泛性寻常疣。据信,该患者多年来长期在面部使用外用皮质类固醇和他克莫司软膏治疗湿疹,导致面部皮肤局部免疫抑制状态,这被认为是寻常疣爆发的一个重要因素。此外,该患者有痤疮病史,经常抓挠面部。抓挠后出现的同形反应被认为是另一个潜在原因。这种治疗实现了完全消退,并改善了患者原有的痤疮问题,在随访期间获得了令人满意的美容效果,没有任何明显的不良反应或复发。这突出表明,在光动力疗法之前进行刮除术预处理提高了寻常疣的治疗效率并降低了成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca6b/11278039/0c8d88f44042/CCID-17-1695-g0001.jpg

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