一锅法在水中由乙基芳烃合成咪唑和噻唑。
One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water.
机构信息
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, Shanghai, China.
出版信息
Molecules. 2019 Mar 4;24(5):893. doi: 10.3390/molecules24050893.
A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.
一种简便、环保的方法已经被开发出来，用于在水中从芳基乙烷合成咪唑和噻唑。该反应通过使用 NBS 作为溴源和氧化剂原位形成α-溴代酮，然后用合适的亲核试剂捕获，在无金属条件下以良好的收率得到相应的产物。
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