WestCHEM, School of Chemistry, The University of Glasgow, Glasgow G12 8QQ, UK.
Science. 2018 Jan 19;359(6373):314-319. doi: 10.1126/science.aao3466.
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the γ-aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities.
化学制造通常在需要大量资本投资的大型设施中进行，然后生产有限时间内的关键化合物。我们提出了一种在独立的塑料反应设备中制造精细化学品和药物的方法。该设备是使用化学到计算机自动化设计（ChemCAD）方法设计和构建的，该方法能够将传统的台式合成转化为独立于平台的数字代码。这反过来又指导了三维打印设备的生产，该设备通过简单的操作将整个合成路线内部封闭起来。我们通过建立一个概念来证明这种方法，该概念为在专业设施之外局部制造药物铺平了道路，即γ-氨基丁酸受体激动剂（±）-baclofen。
